Compile Data Set for Download or QSAR
Report error Found 2307 Enz. Inhib. hit(s) with Target = 'Integrin alpha-V/beta-3'
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123247((S)-3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbony...)
Affinity DataIC50: 0.000920nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50372593(CHEMBL410050)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor high affinity state by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of [125I]echistatin binding to integrin alphaVbeta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 in human NCI-H1975 cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123248((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...)
Affinity DataIC50: 0.0330nMAssay Description:Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50121964(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50107412(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50390490(CHEMBL2071603)
Affinity DataKi:  0.0430nMAssay Description:Displacement of [125I]-c(RGDyK) from human integrin alphavbeta3 after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145527((S)-5-{4-[3-(5-Fluoro-1,4,5,6-tetrahydro-pyrimidin...)
Affinity DataIC50: 0.0550nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145533((S)-2-Benzyloxycarbonylamino-5-oxo-5-{4-[3-(4,5,6,...)
Affinity DataIC50: 0.0560nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145528((S)-2-Benzyloxycarbonylamino-5-oxo-5-{4-[3-(1,4,5,...)
Affinity DataIC50: 0.0580nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataKd:  0.0600nMAssay Description:Dissociation constant of radiolabeled compound binding to alpha-v-beta-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145530((S)-2-Benzyloxycarbonylamino-5-{4-[3-(5-fluoro-1,4...)
Affinity DataIC50: 0.0630nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092512(2-Benzenesulfonylamino-3-{4-[2-(5,6,7,8-tetrahydro...)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092512(2-Benzenesulfonylamino-3-{4-[2-(5,6,7,8-tetrahydro...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50153027((S)-3-Pyrimidin-5-yl-9-(5,6,7,8-tetrahydro-[1,8]na...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50153031((S)-3-(2-Methyl-pyrimidin-5-yl)-9-(5,6,7,8-tetrahy...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50372594(CHEMBL437072)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor high affinity state by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092509((S)-3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoyla...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of binding to human Vitronectin receptor (integrin alphaV-beta3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50392279(CHEMBL2153647)
Affinity DataIC50: 0.0820nMAssay Description:Displacement of [125I]echistatin from integrin alpha5beta3 after 3 hrs by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50329685(CHEMBL1269295)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of biotinylated vitronectin binding to human alphaVbeta3 integrin after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50112996(3-(2-{[5-(3-Benzyl-ureido)-furan-2-carbonyl]-amino...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50100173(3-{N-[N'-(5-guanidinobenzoyl)hydrazino]carbonyl}-a...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50152791((S)-2-((1S,4R)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]he...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of alpha v beta 3 receptor bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50146490(3-(S)-Benzo[1,3]dioxol-5-yl-3-({(R)-5-oxo-1-[3-(1,...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50313793((S)-3-(3-amino-4-(3-(5,6,7,8-tetrahydro-1,8-naphth...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]echistatin from human recombinant alpha-v beta-3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50223890((S)-3-[3'-(2-cyclopropylamino-3,4-dioxo-cyclobut-1...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to integrin alpha-v-beta-3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50134777((S)-3-(2,3-Dihydro-benzofuran-6-yl)-3-{2-oxo-3-[3-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50141329(2-Benzenesulfonylamino-3-{4-[3-(1,4,5,6-tetrahydro...)
Affinity DataIC50: 0.110nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50329686(CHEMBL1269296)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of biotinylated vitronectin binding to human alphaVbeta3 integrin after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50135967(2-((S)-(1R,7S)-7,7-Dimethyl-2-oxo-bicyclo[2.2.1]he...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of binding to human Vitronectin receptor (integrin alphaV-beta3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50153026((S)-3-(2-Methoxy-pyrimidin-5-yl)-9-(5,6,7,8-tetrah...)
Affinity DataIC50: 0.110nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50107410(3-(2,3-Dihydro-benzofuran-6-yl)-3-(2-{2-oxo-3-[2-(...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50141329(2-Benzenesulfonylamino-3-{4-[3-(1,4,5,6-tetrahydro...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards alpha V-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50136246((S)-3-{(R)-2-Oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]-labeled nonpeptide from purified recombinant human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50346319((S)-3-(3-fluoro-4-(4-(1,4,5,6-tetrahydropyrimidin-...)
Affinity DataIC50: 0.140nMAssay Description:Antagonist activity at alphavbeta3 integrin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083763([(S)-8-[2-(6-Methylamino-pyridin-2-yl)-ethoxy]-3-o...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of binding to human Vitronectin receptor (integrin alphaV-beta3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083763([(S)-8-[2-(6-Methylamino-pyridin-2-yl)-ethoxy]-3-o...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145526((S)-2-Benzyloxycarbonylamino-5-{4-[3-(5-hydroxy-1,...)
Affinity DataIC50: 0.150nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50329684(CHEMBL1269294)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of biotinylated vitronectin binding to human alphaVbeta3 integrin after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50329682(CHEMBL1269292)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of biotinylated vitronectin binding to human alphaVbeta3 integrin after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50329683(CHEMBL1269293)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of biotinylated vitronectin binding to human alphaVbeta3 integrin after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50372592(CHEMBL406912)
Affinity DataIC50: 0.160nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor high affinity state by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145525(2-Benzyloxycarbonylamino-5-{4-[3-(4,5-dihydro-1H-i...)
Affinity DataIC50: 0.160nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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