Compile Data Set for Download or QSAR
Report error Found 803 Enz. Inhib. hit(s) with Target = 'Integrin alpha-L'
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107174(1-{3-[4-(2-Methoxy-phenylsulfanyl)-2,3-bis-trifluo...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(2-8)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263757((E)-3-(4-(3-(1-isopropylpiperidin-4-ylamino)phenyl...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50550223(CHEMBL4794300)
Affinity DataIC50: 0.390nMAssay Description:Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50264878(cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-e...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263755((E)-3-(4-(3-(1-methylpiperidin-4-ylamino)phenylthi...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107168(1-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-ylsulfanyl...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(0.03-0.5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263657((cis)-4-(3-(4-((E)-3-morpholino-3-oxoprop-1-enyl)-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50264880((trans)-4-((2-(4-((E)-3-morpholino-3-oxoprop-1-eny...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50: 0.840nMAssay Description:Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263805((E)-1-morpholino-3-(4-(3-(1-propylpiperidin-4-ylam...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263806((E)-3-(4-(3-(8-methyl-8-azabicyclo[3.2.1]octan-3-y...)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263711((E)-1-morpholino-3-(4-(3-(piperidin-4-ylamino)phen...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263710((trans)-4-((3-(4-((E)-3-morpholino-3-oxoprop-1-eny...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263756((E)-3-(4-(3-(1-ethylpiperidin-4-ylamino)phenylthio...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50324826((2S)-2-(2,6-dichloro-4-(3-hydroxy-3-(3-hydroxyphen...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LFA1 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263548((E)-3-(4-(3-aminophenylthio)-2,3-bis(trifluorometh...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50318222(4-((5S,9R)-7-(5-(1H-Tetrazol-5-yl)pyridin-2-yl)-3-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50318219(2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50265320((trans)-4-(2-(4-((E)-3-morpholino-3-oxoprop-1-enyl...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107166(1-{3-[3-Chloro-4-(2,3-dihydro-benzo[1,4]dioxin-6-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (2-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50265147((E)-1-morpholino-3-(4-(2-(piperidin-4-yloxy)phenyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50386338(CHEMBL2048036)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50265190((E)-1-morpholino-3-(4-(3-(tetrahydro-2H-thiopyran-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263656((trans)-4-(3-(4-((E)-3-morpholino-3-oxoprop-1-enyl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50265149((E)-1-morpholino-3-(4-(2-(tetrahydro-2H-pyran-4-yl...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50264778(4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfa...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50318220(6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50199036(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50107168(1-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-ylsulfanyl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM-1) binding to recombinant LFA-1, range(3-6)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50265286((cis)-4-(3-(4-((E)-3-morpholino-3-oxoprop-1-enyl)-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50386328(CHEMBL2048025)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263709((cis)-4-((3-(4-((E)-3-morpholino-3-oxoprop-1-enyl)...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50264879((cis)-4-((3-(4-((E)-3-morpholino-3-oxoprop-1-enyl)...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50264881((trans)-4-((3-(4-((E)-3-morpholino-3-oxoprop-1-eny...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50318228(2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50264876((E)-1-morpholino-3-(4-(2-(pyridin-4-ylmethoxy)phen...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50265148((E)-1-morpholino-3-(4-(3-(piperidin-4-yloxy)phenyl...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107173(1-{3-[3-Chloro-4-(2-methoxy-phenylsulfanyl)-2-trif...)
Affinity DataIC50: 4nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (2-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107176(1-{3-[2,3-Dichloro-4-(1-methyl-1H-indol-5-ylsulfan...)
Affinity DataIC50: 4nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (1-10)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386325(CHEMBL2048402)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50265285((cis)-4-(2-(4-((E)-3-morpholino-3-oxoprop-1-enyl)-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50318231(2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50263596((E)-3-(4-(3-(methylamino)phenylthio)-2,3-bis(trifl...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50318227(2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50318225(2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrin alpha-L(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50107169(1-{3-[4-(1-Methyl-1H-indol-5-ylsulfanyl)-2,3-bis-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM-1) binding to recombinant LFA-1, range(5-5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099130(1-[2-(2,3-Dichloro-4-{2-[3-(2-oxo-pyrrolidin-1-yl)...)
Affinity DataIC50: 5nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107169(1-{3-[4-(1-Methyl-1H-indol-5-ylsulfanyl)-2,3-bis-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(3-10)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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