Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with Target = 'Integrin alpha-2/beta-1'
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538004(CHEMBL4303254)
Affinity DataEC50:  130nMAssay Description:Inhibition of human alpha2 beta1 expressed in CHO cells assessed as reduction in cell adhesion to collagen type 1 incubated for 5 mins by DiOC6 dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538003(CHEMBL4649149)
Affinity DataEC50:  160nMAssay Description:Inhibition of human alpha2 beta1 expressed in CHO cells assessed as reduction in cell adhesion to collagen type 1 incubated for 5 mins by DiOC6 dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446804(CHEMBL3115061)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at alpha2beta1 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538005(CHEMBL4645996)
Affinity DataIC50: 12nMAssay Description:Inhibition of human alpha2 beta1 in human platelets assessed as reduction in platelet adhesion to collagen type 1 incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446821(CHEMBL3115056)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19053((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19066((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19057((2S)-3-({[(4-aminophenyl)methyl]carbamoyl}amino)-2...)
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19063((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataIC50: 29nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446818(CHEMBL3115059)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19065((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataIC50: 35nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446811(CHEMBL3115067)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19070((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(4-met...)
Affinity DataIC50: 36nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446820(CHEMBL3115057)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19064((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-{[3,5-b...)
Affinity DataIC50: 39nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19068((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-(naphth...)
Affinity DataIC50: 50nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19071((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(4-met...)
Affinity DataIC50: 70nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19066((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataIC50: 83nMAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19063((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataIC50: 89nMAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446837(CHEMBL3114869)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19057((2S)-3-({[(4-aminophenyl)methyl]carbamoyl}amino)-2...)
Affinity DataIC50: 102nMAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19072((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(4-nit...)
Affinity DataIC50: 105nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446838(CHEMBL3114868)
Affinity DataIC50: 106nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19058((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 107nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19061((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 108nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446845(CHEMBL3114861)
Affinity DataIC50: 114nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19074((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(4-ace...)
Affinity DataIC50: 131nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446823(CHEMBL3115054)
Affinity DataIC50: 134nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19053((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 138nMAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446843(CHEMBL3114863)
Affinity DataIC50: 142nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19073((2S)-2-{[(2S)-1-[(4-aminobenzene)sulfonyl]pyrrolid...)
Affinity DataIC50: 144nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19075((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-({4-[(p...)
Affinity DataIC50: 151nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19060((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446846(CHEMBL3114860)
Affinity DataIC50: 163nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446805(CHEMBL3115073)
Affinity DataIC50: 176nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19068((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-(naphth...)
Affinity DataIC50: 177nMAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446839(CHEMBL3114867)
Affinity DataIC50: 178nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19052((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 185nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19055((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 185nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50117069((S)-2-(2-Chloro-6-methyl-benzoylamino)-3-[4-(2,6-d...)
Affinity DataIC50: 214nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446844(CHEMBL3114862)
Affinity DataIC50: 233nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19076((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-{[4-(2-...)
Affinity DataIC50: 236nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446807(CHEMBL3115071)
Affinity DataIC50: 270nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19069((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(4-phe...)
Affinity DataIC50: 287nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19056((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 296nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19054((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 357nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1(Human)
Pliant Therapeutics

Curated by ChEMBL
LigandPNGBDBM50446816(CHEMBL3115062)
Affinity DataIC50: 366nMAssay Description:Antagonist activity at recombinant integrin alpha2 beta1 receptor (unknown origin) assessed as inhibition of interaction with biotinylated collagen t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19050((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 367nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-2/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19059((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataIC50: 467nMpH: 7.4 T: 2°CAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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