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TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataEC50: >800nMAssay Description:Potency of compound was tested against HIV-1- containing integrase mutations (T66I, S153Y)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50123468([3-Benzyl-5-(1,1-dioxo-1lambda 6 -isothiazolidin-2...)
Affinity DataEC50:  140nMAssay Description:Potency of compound was tested against HIV-1- containing integrase mutations (NL4-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273902(CHEMBL4126659)
Affinity DataEC50:  27nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273904(CHEMBL4128715)
Affinity DataEC50:  53nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273913(CHEMBL4127663)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273902(CHEMBL4126659)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273914(CHEMBL4126686)
Affinity DataEC50:  21nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273915(CHEMBL4127891)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273948(CHEMBL4127873)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273949(CHEMBL4128924)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273950(CHEMBL4128240)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273951(CHEMBL4126165)
Affinity DataEC50:  5nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273952(CHEMBL4130102)
Affinity DataEC50:  7nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273953(CHEMBL4126840)
Affinity DataEC50:  12nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273963(CHEMBL4128890)
Affinity DataEC50:  6nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273964(CHEMBL4130252)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273965(CHEMBL4127923)
Affinity DataEC50:  19nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273904(CHEMBL4128715)
Affinity DataEC50:  857nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273914(CHEMBL4126686)
Affinity DataEC50:  557nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273915(CHEMBL4127891)
Affinity DataEC50:  84nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273913(CHEMBL4127663)
Affinity DataEC50:  90nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataEC50:  17nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273948(CHEMBL4127873)
Affinity DataEC50:  21nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273949(CHEMBL4128924)
Affinity DataEC50:  14nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273950(CHEMBL4128240)
Affinity DataEC50:  8nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273951(CHEMBL4126165)
Affinity DataEC50:  149nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273903(CHEMBL4129717)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataEC50:  25nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 40% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273903(CHEMBL4129717)
Affinity DataEC50:  19nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serum and 10% human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273952(CHEMBL4130102)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273953(CHEMBL4126840)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273963(CHEMBL4128890)
Affinity DataEC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273964(CHEMBL4130252)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273965(CHEMBL4127923)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50453727(CHEMBL4214002)
Affinity DataKd:  2.07E+5nMAssay Description:Binding affinity to HIV1 integrase by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50453728(CHEMBL4218163)
Affinity DataKd:  1.60E+5nMAssay Description:Binding affinity to HIV1 integrase by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50453729(CHEMBL4206186)
Affinity DataKd:  1.15E+5nMAssay Description:Binding affinity to HIV1 integrase by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50453730(CHEMBL4206051)
Affinity DataKd:  1.42E+5nMAssay Description:Binding affinity to HIV1 integrase by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467936(CHEMBL4293598)
Affinity DataEC50:  2.11E+3nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467937(CHEMBL4277244)
Affinity DataEC50:  1.32E+3nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467938(CHEMBL4289649)
Affinity DataEC50:  1.11E+4nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467939(CHEMBL4278316)
Affinity DataEC50:  4.51E+3nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467940(CHEMBL4294452)
Affinity DataEC50:  350nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467941(CHEMBL4286230)
Affinity DataEC50:  8.39E+3nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467942(CHEMBL4292417)
Affinity DataEC50:  260nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467943(CHEMBL4289243)
Affinity DataEC50:  1.39E+3nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467944(CHEMBL4280676)
Affinity DataEC50:  720nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467945(CHEMBL4291455)
Affinity DataEC50:  27nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50467946(CHEMBL4280849)
Affinity DataEC50:  8.41E+3nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
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