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Report error Found 90 Enz. Inhib. hit(s) with Target = 'Hydroxycarboxylic acid receptor 3'
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50337038(5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyra...)
Affinity DataEC50:  300nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475626(CHEMBL372727)
Affinity DataEC50:  257nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50241028(1-Isopropyl-1H-benzotriazole-5-carboxylic acid | 1...)
Affinity DataEC50:  398nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23515(pyridine-3-carboxylic acid | CHEMBL573 | [5, 6-3H]...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384612(CHEMBL2036958)
Affinity DataEC50:  96nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384641(CHEMBL2036955)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384640(CHEMBL2036954)
Affinity DataEC50:  67nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384637(CHEMBL2036951)
Affinity DataEC50:  59nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384634(CHEMBL2036948)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384616(CHEMBL2036813)
Affinity DataEC50:  190nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23515(pyridine-3-carboxylic acid | CHEMBL573 | [5, 6-3H]...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475627(CHEMBL202657)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50337024(2-(difluoromethyl)-5-(3-(1-methylcyclopropyl)propy...)
Affinity DataEC50:  1.12E+3nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208122(5-(5-chlorothiophen-3-yl)-5-methyl-4-oxo-4,5-dihyd...)
Affinity DataEC50:  1.72E+3nMAssay Description:Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208137(5-(5-bromothiophen-3-yl)-5-methyl-4-oxo-4,5-dihydr...)
Affinity DataEC50:  1.47E+3nMAssay Description:Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50414503(CHEMBL553912)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50414501(CHEMBL562933)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50414497(CHEMBL564064)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-...)
Affinity DataEC50:  4.20E+3nMAssay Description:Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50414496(CHEMBL564907)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50220833(5-(5-propyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL...)
Affinity DataEC50:  724nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50414506(CHEMBL553415)
Affinity DataEC50:  4.47E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475637(CHEMBL202206)
Affinity DataEC50:  331nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-...)
Affinity DataEC50:  316nMAssay Description:Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475646(CHEMBL201278)
Affinity DataEC50:  9.12E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475645(CHEMBL202157)
Affinity DataEC50:  316nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475644(CHEMBL383099)
Affinity DataEC50:  5.89E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475643(CHEMBL370386)
Affinity DataEC50:  3.02E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475642(CHEMBL201513)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475641(CHEMBL440041)
Affinity DataEC50:  3.09E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475640(CHEMBL380939)
Affinity DataEC50:  2.34E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475639(CHEMBL201409)
Affinity DataEC50:  302nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475638(CHEMBL201724)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50414493(CHEMBL565055)
Affinity DataEC50:  8.91E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475636(CHEMBL383367)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475635(CHEMBL202586)
Affinity DataEC50:  692nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475634(CHEMBL202427)
Affinity DataEC50:  5.01E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475633(CHEMBL440217)
Affinity DataEC50:  891nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475632(CHEMBL382863)
Affinity DataEC50:  3.39E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475631(CHEMBL202351)
Affinity DataEC50:  257nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475630(CHEMBL382096)
Affinity DataEC50:  200nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475629(CHEMBL201048)
Affinity DataEC50:  288nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50475628(CHEMBL202614)
Affinity DataEC50:  7.41E+3nMAssay Description:Agonistic activity at GPR109b by cAMP whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208137(5-(5-bromothiophen-3-yl)-5-methyl-4-oxo-4,5-dihydr...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208128(5-(3,4-difluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro...)
Affinity DataEC50:  1.90E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208121(5-(2,4-difluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro...)
Affinity DataEC50:  2.40E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208141(5-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-4,5-di...)
Affinity DataEC50:  1.26E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208124(5-(3-ethyl-phenyl)-5-methyl-4-oxo-4,5-dihydro-fura...)
Affinity DataEC50:  6.20E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208110(5-methyl-5-(4-bromo-thiophen-2-yl)-4-oxo-4,5-dihyd...)
Affinity DataEC50:  4.10E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50208125(5-ethyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxy...)
Affinity DataEC50:  4.80E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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