Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with Target = 'Homoserine kinase'
TargetHomoserine kinase(Escherichia coli (strain K12))
Mcmaster University

LigandPNGBDBM85124(Thr1 inhibitor, 4)
Affinity DataKi:  460nM ΔG°:  -37.6kJ/molepH: 7.5 T: 2°CAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHomoserine kinase(Escherichia coli (strain K12))
Mcmaster University

LigandPNGBDBM85126(Thr1 inhibitor, 6)
Affinity DataKi:  8.60E+3nM ΔG°:  -30.1kJ/molepH: 7.5 T: 2°CAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHomoserine kinase(Escherichia coli (strain K12))
Mcmaster University

LigandPNGBDBM24941(CHEMBL228043 | alpha-cyano-beta-hydroxy-beta-methy...)
Affinity DataKi:  1.20E+4nM ΔG°:  -29.2kJ/molepH: 7.5 T: 2°CAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHomoserine kinase(Escherichia coli (strain K12))
Mcmaster University

LigandPNGBDBM85123(cid_235240 | Thr1 inhibitor, 3)
Affinity DataKi:  2.71E+4nM ΔG°:  -27.1kJ/molepH: 7.5 T: 2°CAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHomoserine kinase(Escherichia coli (strain K12))
Mcmaster University

LigandPNGBDBM85122(Thr1 inhibitor, 1)
Affinity DataKi:  3.20E+4nM ΔG°:  -26.7kJ/molepH: 7.5 T: 2°CAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHomoserine kinase(Escherichia coli (strain K12))
Mcmaster University

LigandPNGBDBM85125(Thr1 inhibitor, 5)
Affinity DataKi:  3.58E+4nM ΔG°:  -26.4kJ/molepH: 7.5 T: 2°CAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed