Report error Found 40 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase, H3 lysine-36 specific'
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataKd: 1.40E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataKd: 4.70E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataKd: 1.20E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataKd: 1.04E+4nMAssay Description:Inhibition of NSD1 (unknown origin) by ITC assay assessed as dissociation constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataKd: 1.00E+7nMAssay Description:Binding affinity to NSD1 SET domain(1852 to 2085 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataKd: 1.04E+4nMAssay Description:Binding affinity to hexa-histidine tagged NSD1 SET domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Ligand Info
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of NSD1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 214nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 225nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 248nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of NSD1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 1...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of NSD1 (unknown origin) measured after 16 hrs by MS assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 4...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of NSD1 (unknown origin) measured after 4 hrs by MS assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) using histone peptide/SAM as substrate by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human NSD1 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human NSD1 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 2...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human NSD1 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 2...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of NSD1 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of NSD1 (unknown origin) preincubated for 15 mins followed by [3H]-SAM addition measured after 4 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human NSD1-SET using histone H3.1 as substrate incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human NSD1 SET domain assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human recombinant NSD1 (5475 to 6345 residues) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by scintillation/filter ass...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 4.18E+5nMAssay Description:Inhibition of human NSD1 SET domain using histone H3 as substrate assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 4.18E+5nMAssay Description:Inhibition of NSD1 (unknown origin) using H3K36 as substrateMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 6.60E+7nMAssay Description:Inhibition of NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 1 hrs followed by HM...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 1 hrs followed by HM...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
