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Report error Found 172 Enz. Inhib. hit(s) with Target = 'High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A'
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50344016(2-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50344017(1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50344018(trans-(3R,5R)-5-ethyl-1-((5-methyl-2-phenyloxazol-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50390334(CHEMBL2070735)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555231(CHEMBL4762103)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM135584(US8846654, 294)
Affinity DataIC50: 15nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50555230(CHEMBL4753446)
Affinity DataIC50: 26nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555224(CHEMBL4790482)
Affinity DataIC50: 46nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555221(CHEMBL4800434)
Affinity DataIC50: 130nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM135577(US8846654, 11)
Affinity DataIC50: 140nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50621423(CHEMBL5407967)
Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant PDE8A1 (480 to 828 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]cAMP as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoSimilars
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PubMed
LigandPNGBDBM50555225(CHEMBL4789101)
Affinity DataIC50: 220nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555220(CHEMBL4778928)
Affinity DataIC50: 240nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555222(CHEMBL4798107)
Affinity DataIC50: 250nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555223(CHEMBL4745958)
Affinity DataIC50: 250nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50407428(CHEMBL5288859)
Affinity DataIC50: 280nMAssay Description:Inhibition of PDE8A (unknown origin) using cAMP as substrate incubated for 30 mins by Ba(OH)2 precipitation assay based scintillation counterMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50555229(CHEMBL4757863)
Affinity DataIC50: 360nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM135583(US8846654, 251)
Affinity DataIC50: 390nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50555227(CHEMBL4747327)
Affinity DataIC50: 410nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23620(Dipyridamine | SMR000058382 | MLS000028420 | CHEMB...)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50357870(CHEMBL1916130)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555228(CHEMBL4750412)
Affinity DataIC50: 660nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575152(CHEMBL4877549)
Affinity DataIC50: 710nMAssay Description:Inhibition of PDE8A1 (480-828) (unknown origin) expressed in Escherichia coli BL21 assessed as using [3H]-cAMP as substrate measured for 15 mins by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 820nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50555226(CHEMBL4786234)
Affinity DataIC50: 920nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE8aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50356427(CHEMBL1911559)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50357825(CHEMBL1915891)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50357826(CHEMBL1915892)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50357871(CHEMBL1916131)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50357872(CHEMBL1916132)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50357234(CHEMBL1916475)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50540044(CHEMBL4644729)
Affinity DataIC50: 2.02E+3nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50555232(CHEMBL4790086)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50467472(CHEMBL4281766)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE8A1 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as sub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246909(CHEMBL4075951)
Affinity DataIC50: 3.56E+3nMAssay Description:Inhibition of human recombinant PDE8A1 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM123687(US8741907, 3 | US9067945, 2)
Affinity DataIC50: 4.00E+3nMpH: 7.5Assay Description:The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. 2 uL portions of the diluted substa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM123687(US8741907, 3 | US9067945, 2)
Affinity DataIC50: 4.00E+3nMpH: 7.5Assay Description:The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50467488(CHEMBL4286052)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE8A1 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as sub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23620(Dipyridamine | SMR000058382 | MLS000028420 | CHEMB...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant PDE8A expressed in baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50356428(CHEMBL1911572)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50319165(2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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