Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,S526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]'
LigandPNGBDBM518(Viracept | CHEMBL584 | (3S,4aS,8aS)-N-tert-butyl-2...)
Affinity DataKi:  722nM ΔG°:  -35.1kJ/molepH: 5.0 T: 2°CAssay Description:Protease activity was determined by following the increase in fluorescence with hydrolysis of the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Ty...More data for this Ligand-Target Pair
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LigandPNGBDBM517(Crixivan | CHEMBL115 | L-735, 524 | MK639 | Indina...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.0kJ/molepH: 5.0 T: 2°CAssay Description:Protease activity was determined by following the increase in fluorescence with hydrolysis of the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Ty...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM519(SQV | Invirase | CHEMBL114 | Ro 31-8959 | Fortovas...)
Affinity DataKi:  1.95E+3nM ΔG°:  -32.6kJ/molepH: 5.0 T: 2°CAssay Description:Protease activity was determined by following the increase in fluorescence with hydrolysis of the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Ty...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM520(ABT-538 | Norvir | CHEMBL163 | 1,3-thiazol-5-ylmet...)
Affinity DataKi:  2.11E+3nM ΔG°:  -32.4kJ/molepH: 5.0 T: 2°CAssay Description:Protease activity was determined by following the increase in fluorescence with hydrolysis of the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Ty...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed