Compile Data Set for Download or QSAR
Report error Found 1965 Enz. Inhib. hit(s) with Target = 'GTPase KRas [1-169,G12C,C118A]'
LigandPNGBDBM653019(US20240059703, Example 2-111 | (M)-1-(6- ((1S,8R)-...)
Affinity DataIC50: 3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM50573426(CHEMBL4867096 | US20240190862, Example 20)
Affinity DataIC50: 5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM50573427(CHEMBL4879059 | US20240190862, Example 21)
Affinity DataIC50: 5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM652997(1-(6-(3-chloro- 4-(1,6-dimethyl- 1H-indazol-7- yl)...)
Affinity DataIC50: 5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544157(US11285156, Ex.# 100-4 | 6-Chloro-1-(4,6- diisopro...)
Affinity DataIC50: 6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544213(US11285156, Ex.# 108-1-2 | 6-Chloro-1-(4- cyclopro...)
Affinity DataIC50: 6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM652949(US20240059703, Example 2-42 | US20240059703, Examp...)
Affinity DataIC50: 6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544106(US11285156, Ex.# 92-61 | (M)-6-Chloro- 7-(2,4- dif...)
Affinity DataIC50: 8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544213(US11285156, Ex.# 108-1-2 | 6-Chloro-1-(4- cyclopro...)
Affinity DataIC50: 8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544283(US11285156, Ex.# 129-9 | (M)-N-[2-[6- Chloro-4- [(...)
Affinity DataIC50: 8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653472(US20240059703, Example 23-3 | US20240059703, Examp...)
Affinity DataIC50: 8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544212(US11285156, Ex.# 108-1)
Affinity DataIC50: 9nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM652946(US20240059703, Example 2-40 | (P)-(1R,8S)-6- (3-hy...)
Affinity DataIC50: 9nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM515895(US11053226, Example 1-4 | 2-(5-Chloro-2- cycloprop...)
Affinity DataIC50: 10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM548364(WO2022093856, Example 1-59)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022093856

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544107(US11285156, Ex.# 92-62 | (M)-6-Chloro- 4-[(2S,5R)-...)
Affinity DataIC50: 10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544382(US11285156, Ex.# 197-2 | 4-((2S,5R)-4-Acryloyl-2,5...)
Affinity DataIC50: 10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653301(US20240059703, Example 14-72 | 1-(6-((1R,9R)-5-flu...)
Affinity DataIC50: 10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653277(US20240059703, Example 14-48 | US20240059703, Exam...)
Affinity DataIC50: 11nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653092(US20240059703, Example 13-20 | (7R)-4-(2-chlorophe...)
Affinity DataIC50: 12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653165(US20240059703, Example 13-114 | (6R,8R)-2-(2-acryl...)
Affinity DataIC50: 12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653162(US20240059703, Example 13-91 | US20240059703, Exam...)
Affinity DataIC50: 13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653180(US20240059703, Example 13-108 | (1R,9R)-6-(3-hydro...)
Affinity DataIC50: 13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653305(US20240059703, Example 14-76 | US20240059703, Exam...)
Affinity DataIC50: 13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653336(US20240059703, Example 14-107 | (M)-1-(6-(4-(5-chl...)
Affinity DataIC50: 13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544076(US11285156, Ex.# 92-31 | (M)-7-(2- Amino-4,5- difl...)
Affinity DataIC50: 14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544428(US11285156, Ex.# 222-2)
Affinity DataIC50: 14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM652855((P)-7,7-dimethyl-4-(5- methyl-1H-indazol-4-yl)- 2-...)
Affinity DataIC50: 14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653233(US20240059703, Example 14-4 | US20240059703, Examp...)
Affinity DataIC50: 14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653439(US20240059703, Example 21-13 | US20240059703, Exam...)
Affinity DataIC50: 14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM688685(US20240190862, Example 37 | 7-(2-Amino-6-fluorophe...)
Affinity DataIC50: 15nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM652975(US20240059703, Example 2-68 | (1R,9R)-6-(5- hydrox...)
Affinity DataIC50: 15nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544046(US11285156, Ex.# 92-1)
Affinity DataIC50: 16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653113(US20240059703, Example 13-41 | 4-(3-hydroxy-1- nap...)
Affinity DataIC50: 16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653320(US20240059703, Example 14-91 | 4-(5-chloro-6-methy...)
Affinity DataIC50: 16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653015(US20240059703, Example 2-107 | 8-(5-chloro-1,6- di...)
Affinity DataIC50: 17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653126(US20240059703, Example 13-54 | (P)-6,6-dimethyl-4-...)
Affinity DataIC50: 17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653233(US20240059703, Example 14-4 | US20240059703, Examp...)
Affinity DataIC50: 17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653371(US20240059703, Example 18-4 | (P)-1-(6-(4-(6-hydro...)
Affinity DataIC50: 17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM50573429(CHEMBL4852058 | US20240190862, Example 27)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing either G12C or G12D, as well as C118A amino acid substitutions and an N-terminal His-tag, was ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM652984(US20240059703, Example 2-76 | US20240059703, Examp...)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653012(US20240059703, Example 2-104 | 8-(5-chloro-1,6- di...)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653230(US20240059703, Example 14-1)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653439(US20240059703, Example 21-13 | US20240059703, Exam...)
Affinity DataIC50: 18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM548305(WO2022093856, Example 1-2)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022093856

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544057(US11285156, Ex.# 92-12 | (M)-7-(2- Aminophenyl)- 6...)
Affinity DataIC50: 19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544069(US11285156, Ex.# 92-24 | (M)-2-[6- Chloro-4- [(2S,...)
Affinity DataIC50: 19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653001(US20240059703, Example 2-93 | 1-(5-methyl-1H- inda...)
Affinity DataIC50: 19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653473(US20240059703, Example 23-4 | US20240059703, Examp...)
Affinity DataIC50: 19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
AMGEN INC.

US Patent
LigandPNGBDBM544105(US11285156, Ex.# 92-60 | (M)-6-Chloro- 4-[(2S,5R)-...)
Affinity DataIC50: 20nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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