Report error Found 1137 Enz. Inhib. hit(s) with Target = 'GABA-A receptor; alpha-5/beta-3/gamma-2'
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 4.20E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 6.90E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 7.50E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 4.20E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.90E+6nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.00E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.60E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Inverse agonist activity at GABAA alpha5beta3gamma2 in Homo sapiens (human) L(tk-) cells by patch clamp assayMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.5nMAssay Description:Effective concentration against human Alpha-5-beta-3-gamma-2 GABA-A receptor was determinedMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 45nMAssay Description:Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.13E+3nMAssay Description:Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 455nMAssay Description:Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 206nMAssay Description:Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Binding affinity to human recombinant GABAA alpha5beta3gamma2 expressed in Xenopus laevis oocytes by patch clamp techniqueMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.94E+4nMAssay Description:Negative allosteric modulation activity at human GABAA alpha5beta3gamma2 stably expressed in HEK cells by patch clamp methodMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.0800nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABA-Aalpha5 receptor plus beta3gamma2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Displacement of [3H]-Ro15-1788 from human GABAA alpha5beta3gamma2 expressed in HEK293 cell membranes incubated for 40 or 90 mins by liquid scintillat...More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Binding affinity for Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABA-Aalpha5 receptor plus beta-3-gamma-2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABA-Aalpha5 receptor plus beta3gamma2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.190nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.190nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABA-Aalpha5 receptor plus beta3gamma2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]Flumazenil from human GABA alpha-5-beta-3-gamma-2 receptor expressed in insect SF9 cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]Flumazenil from cloned human GABA alpha-5-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.210nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.210nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.230nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta3gamma2 expressed in Ltk cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.25nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.260nMAssay Description:Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.260nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABAA alpha5 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
