Compile Data Set for Download or QSAR
Report error Found 159 Enz. Inhib. hit(s) with Target = 'G-protein coupled estrogen receptor 1'
TargetG-protein coupled estrogen receptor 1(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against rat GPR41 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303803(cid_5322399 | cid_3136849 | CHEMBL569766 | 1-((3aS...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at GPR30 (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303803(cid_5322399 | cid_3136849 | CHEMBL569766 | 1-((3aS...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at GPR30 (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303803(cid_5322399 | cid_3136849 | CHEMBL569766 | 1-((3aS...)
Affinity DataEC50:  1.45E+3nMAssay Description:Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50459749(CHEMBL4204236)
Affinity DataEC50:  20nMAssay Description:Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50459750(CHEMBL4204670)
Affinity DataEC50:  480nMAssay Description:Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50459751(CHEMBL4212956)
Affinity DataEC50:  1.62E+3nMAssay Description:Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288677(US10087191, Example 94)
Affinity DataIC50: 0.0400nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288659(US10087191, Example 74)
Affinity DataIC50: 0.210nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288672((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 0.210nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288680(US10087191, Example 97)
Affinity DataIC50: 0.240nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288611( (E)-3-(4-((1S,3R)-6-(1-(difluoromethyl)-1H-pyrazo...)
Affinity DataIC50: 0.290nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288653(US10087191, Example 68)
Affinity DataIC50: 0.310nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288605((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 0.320nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288616(US10087191, Example 21)
Affinity DataIC50: 0.320nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288643(US10087191, Example 57)
Affinity DataIC50: 0.330nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288673((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 0.360nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288675((E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-(7-isobutyl-8...)
Affinity DataIC50: 0.430nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288658((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-5-fluoro-2-(2...)
Affinity DataIC50: 0.450nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288619(US10087191, Example 25)
Affinity DataIC50: 0.510nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288608((E)-3-(3,5-difluoro-4-((1S,3R)-2-(2-fluoro-2-methy...)
Affinity DataIC50: 0.640nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288684((E)-3-(4-((6R,8R/6S,8S)-7-isobutyl-8-methyl-6,7,8,...)
Affinity DataIC50: 0.640nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288601((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 0.720nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288602((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 0.730nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288656(US10087191, Example 71)
Affinity DataIC50: 0.740nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288436((E)-3-(3,5-difluoro-4-((5S,7R/5R,7S)-6-(2-fluoro-2...)
Affinity DataIC50: 0.770nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288655((E)-3-(3,5-difluoro-4-((6S,8R/6R,8S)-7-(2-fluoro-2...)
Affinity DataIC50: 0.770nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288642((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 0.820nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288644((E)-3-(4-((1S,3R/1R,3S)-6-(1-cyclopropyl-1H-pyrazo...)
Affinity DataIC50: 0.840nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288681(US10087191, Example 98)
Affinity DataIC50: 0.850nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288615((E)-3-(4-((1S,3R/1R,3S)-6-(1-ethyl-1H-pyrazol -4-y...)
Affinity DataIC50: 0.860nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288633((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-5-fluoro-2-(2...)
Affinity DataIC50: 0.870nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288650(US10087191, Example 64)
Affinity DataIC50: 1.07nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288613((E)-3-(4-((1S,3R/1R,3S)-6-(1-ethyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 1.17nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288671((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.22nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288603((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.25nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288607((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.26nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288685((E)-3-(4-((6S,8R/6R,8S)-7-cyclopentyl-8-methyl-6,7...)
Affinity DataIC50: 1.32nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288612((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-7-fluoro-2-(2...)
Affinity DataIC50: 1.36nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288660((E)-3-(4-((1R,3R/1S,3S)-6-(1-ethyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 1.39nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288623((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.45nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288635((E)-3-(4-((1S,3R/1R,3S)-6-(1-ethyl-1H-pyrazol-4-yl...)
Affinity DataIC50: 1.5nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288614((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.52nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288618((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.59nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288649((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.70nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288636((E)-3-(3,5-difluoro-4-((1S,3R/1R,3S)-2-(2-fluoro-2...)
Affinity DataIC50: 1.82nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288606(US10087191, Example 8)
Affinity DataIC50: 1.85nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG-protein coupled estrogen receptor 1(Human)
University of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM288674((E)-3-(3,5-difluoro-4-((5S,7R/5R,7S)-6-(2-fluoro-2...)
Affinity DataIC50: 1.88nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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