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Report error Found 320 Enz. Inhib. hit(s) with Target = 'G protein-coupled receptor kinase 5'
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50554259(CHEMBL4788026)
Affinity DataKd: >8.33E+4nMAssay Description:Binding affinity to GRK5 (unknown origin) by Thermofluor thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50554260(CHEMBL4776422)
Affinity DataKd: >8.33E+4nMAssay Description:Binding affinity to GRK5 (unknown origin) by Thermofluor thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50554261(CHEMBL4742242)
Affinity DataKd: >8.33E+4nMAssay Description:Binding affinity to GRK5 (unknown origin) by Thermofluor thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50554262(CHEMBL4791786)
Affinity DataKd: >8.33E+4nMAssay Description:Binding affinity to GRK5 (unknown origin) by Thermofluor thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50554263(CHEMBL4740635)
Affinity DataKd:  3.43E+4nMAssay Description:Binding affinity to GRK5 (unknown origin) by Thermofluor thermal shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566206(CHEMBL4786599)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566201(CHEMBL4785430)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566949(CHEMBL4877302)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant full length human GRK5 using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566189(CHEMBL4800665)
Affinity DataIC50: 15nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566212(CHEMBL4780266)
Affinity DataIC50: 15nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50624686(CHEMBL5415336)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566191(CHEMBL4782014)
Affinity DataIC50: 21nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 24.6nMAssay Description:Inhibition of human GRK5 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566946(CHEMBL4854871)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant full length human GRK5 using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566205(CHEMBL4794078)
Affinity DataIC50: 29nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566192(CHEMBL4781735)
Affinity DataIC50: 48nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566947(CHEMBL4847703)
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant full length human GRK5 using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50444090(CHEMBL3093151)
Affinity DataIC50: 59nMAssay Description:Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 73.3nMAssay Description:Inhibition of human GRK5 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566202(CHEMBL4787507)
Affinity DataIC50: 80nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566215(CHEMBL4779427)
Affinity DataIC50: 87nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566193(CHEMBL4786185)
Affinity DataIC50: 91nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566216(CHEMBL4786846)
Affinity DataIC50: 95nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566211(CHEMBL4799210)
Affinity DataIC50: 110nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50444135(CHEMBL3093260)
Affinity DataIC50: 120nMAssay Description:Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566207(CHEMBL4777196)
Affinity DataIC50: 130nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566213(CHEMBL4784634)
Affinity DataIC50: 130nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50444137(CHEMBL3093258)
Affinity DataIC50: 140nMAssay Description:Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM283998(US10023564, Example 24 | E24)
Affinity DataIC50: 140nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566209(CHEMBL4798127)
Affinity DataIC50: 140nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 160nMAssay Description:Inhibition of GRK5-mediated bovine tubulin phosphorylation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50384021(CHEMBL2079205 | CHEMBL2032283)
Affinity DataIC50: 210nMAssay Description:Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 220nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50529470(CHEMBL4475305)
Affinity DataIC50: 220nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 0 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566199(CHEMBL4791260)
Affinity DataIC50: 220nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 220nMAssay Description:Time dependent inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM283998(US10023564, Example 24 | E24)
Affinity DataIC50: 260nMAssay Description:Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50529470(CHEMBL4475305)
Affinity DataIC50: 260nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 30 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50624683(CHEMBL5412633)
Affinity DataIC50: 260nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50529470(CHEMBL4475305)
Affinity DataIC50: 270nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 60 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50173310(CHEMBL3808660 | US10023564, Example 1)
Affinity DataIC50: 280nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566203(CHEMBL4786913)
Affinity DataIC50: 280nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50529469(CHEMBL4456539)
Affinity DataIC50: 300nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 30 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50529469(CHEMBL4456539)
Affinity DataIC50: 350nMAssay Description:Inhibition of human GRK5 using tubulin as substrate measured after 60 mins by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50444098(CHEMBL3093253)
Affinity DataIC50: 360nMAssay Description:Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50566200(CHEMBL4793010)
Affinity DataIC50: 360nMAssay Description:Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for 3 to 5 mins by [gamma32P]ATP based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50173310(CHEMBL3808660 | US10023564, Example 1)
Affinity DataIC50: 380nMAssay Description:Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50173310(CHEMBL3808660 | US10023564, Example 1)
Affinity DataIC50: 380nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 380nMAssay Description:Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 380nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
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