Compile Data Set for Download or QSAR
Report error Found 2839 Enz. Inhib. hit(s) with Target = 'Fatty acid synthase'
TargetFatty acid synthase [2202-2509](Human)
Texas A&M University

LigandPNGBDBM24972((2S)-1-[(2S,3S)-3-hexyl-4-oxoazetidin-2-yl]trideca...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase [2202-2509](Human)
Texas A&M University

LigandPNGBDBM24973((2R)-1-[(2R,3R)-3-hexyl-4-oxoazetidin-2-yl]trideca...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase [2202-2509](Human)
Texas A&M University

LigandPNGBDBM24974((2S)-1-[(2S,3S)-3-hexyl-4-oxoazetidin-2-yl]heptan-...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM128366(US8802864, 132)
Affinity DataIC50: 3nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50124410(CHEMBL3623457)
Affinity DataIC50: 3nMAssay Description:Inhibition of fatty acid synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM128362(US8802864, 42)
Affinity DataIC50: 5nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244437(US9428502, 46 | US10226449, cpd 46)
Affinity DataIC50: 5nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244437(US9428502, 46 | US10226449, cpd 46)
Affinity DataIC50: 5nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244437(US9428502, 46 | US10226449, cpd 46)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM128359(US8802864, 14)
Affinity DataIC50: 6nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244398(US9428502, 7 | US10226449, cpd 7)
Affinity DataIC50: 6nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244404(US9428502, 13 | US10226449, cpd 13)
Affinity DataIC50: 6nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50124413(CHEMBL3623460)
Affinity DataIC50: 6nMAssay Description:Inhibition of fatty acid synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50391838(CHEMBL2147033)
Affinity DataIC50: 6nMAssay Description:Inhibition of fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244398(US9428502, 7 | US10226449, cpd 7)
Affinity DataIC50: 6nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244404(US9428502, 13 | US10226449, cpd 13)
Affinity DataIC50: 6nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244398(US9428502, 7 | US10226449, cpd 7)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244404(US9428502, 13 | US10226449, cpd 13)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244435(US9428502, 44 | US10226449, cpd 44)
Affinity DataIC50: 7nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244438(US9428502, 47 | US10226449, cpd 47)
Affinity DataIC50: 7nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244435(US9428502, 44 | US10226449, cpd 44)
Affinity DataIC50: 7nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244438(US9428502, 47 | US10226449, cpd 47)
Affinity DataIC50: 7nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244435(US9428502, 44 | US10226449, cpd 44)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244438(US9428502, 47 | US10226449, cpd 47)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM119133((S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cycloprop...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of FAS by GSK2194069 was measured by an endpoint assay for thiols using a fluorescent maleimide.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50124411(CHEMBL3623458)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of fatty acid synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244581(US9428502, 190 | US10226449, cpd 190)
Affinity DataIC50: 8nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244581(US9428502, 190 | US10226449, cpd 190)
Affinity DataIC50: 8nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244581(US9428502, 190 | US10226449, cpd 190)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244418(US9428502, 27 | US10226449, cpd 27)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244436(US9428502, 45 | US10226449, cpd 45)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244439(US9428502, 48 | US10226449, cpd 48)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244440(US9428502, 49 | US10226449, cpd 49)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244575(US9428502, 184 | US10226449, cpd 184)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244632(US9428502, 241 | US10226449, cpd 241)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244743(US9428502, 353 | US10226449, cpd 353)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244769(US9428502, 381 | US10226449, cpd 381)
Affinity DataIC50: 9nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244418(US9428502, 27 | US10226449, cpd 27)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244436(US9428502, 45 | US10226449, cpd 45)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244439(US9428502, 48 | US10226449, cpd 48)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244440(US9428502, 49 | US10226449, cpd 49)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244575(US9428502, 184 | US10226449, cpd 184)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244632(US9428502, 241 | US10226449, cpd 241)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244743(US9428502, 353 | US10226449, cpd 353)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244769(US9428502, 381 | US10226449, cpd 381)
Affinity DataIC50: 9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244418(US9428502, 27 | US10226449, cpd 27)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGUS20250017938, Compound 002-45(US9428502, 235 | US10226449, cpd 235)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244439(US9428502, 48 | US10226449, cpd 48)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244440(US9428502, 49 | US10226449, cpd 49)
In DepthDetails

TargetFatty acid synthase(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM244575(US9428502, 184 | US10226449, cpd 184)
In DepthDetails

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