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Report error Found 1005 Enz. Inhib. hit(s) with Target = 'Farnesyl pyrophosphate synthase'
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50432306(CHEMBL2347862)
Affinity DataKd:  3.20E+3nMAssay Description:Binding affinity to human FPPS by isothermal titration colorimetry in absence of Mg2+ ionsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50022663(CHEMBL3299047)
Affinity DataKd:  9.20E+3nMAssay Description:Binding affinity to human FPPS by isothermal titration colorimetry in absence of Mg2+ ionsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  1.21E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H14-H15 of isopent...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  5.50E+5nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H11 of isopentenyl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  2.21E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H12 of isopentenyl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  2.02E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H2/H8 of purine ri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531174(CHEMBL4550442)
Affinity DataKd:  448nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531177(CHEMBL4544242)
Affinity DataKd:  8.16E+3nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531177(CHEMBL4544242)
Affinity DataKd:  8.16E+3nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531187(CHEMBL4586056)
Affinity DataKd:  61.6nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531179(Methyl Carnosate)
Affinity DataKd:  360nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531174(CHEMBL4550442)
Affinity DataKd:  448nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531179(Methyl Carnosate)
Affinity DataKd:  360nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50531187(CHEMBL4586056)
Affinity DataKd:  61.6nMAssay Description:Binding affinity to human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) by surface plasmon re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50466400(CHEMBL1818656)
Affinity DataKd:  4.81E+4nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50245886(4-formylphenyl-O-beta-Dglucopyranoside | 4-((2S,3R...)
Affinity DataKd:  3.28E+5nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559030(CHEMBL4748453)
Affinity DataKd:  2.57E+4nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559031(CHEMBL2137967)
Affinity DataKd:  7.20E+4nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559032(CHEMBL1596034)
Affinity DataKd:  4.99E+5nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559033(CHEMBL4761604)
Affinity DataKd:  4.42E+5nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559034(CHEMBL4785030)
Affinity DataKd:  1.43E+4nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559035(CHEMBL4764217)
Affinity DataKd:  1.06E+5nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559036(CHEMBL4794885)
Affinity DataKd:  5.38E+4nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Rat)
Jiangsu Institute of Nuclear Medicine

Curated by ChEMBL
LigandPNGBDBM50559037(CHEMBL4753538)
Affinity DataKd:  1.81E+5nMAssay Description:Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 0.240nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12576(JMC515594 Compound 64 | Risdronate | CHEMBL923 | R...)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human FPPS using pre-incubation of compound with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422472(CHEMBL100827)
Affinity DataIC50: 0.620nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 1nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50098389([1-Hydroxy-2-(1H-imidazol-4-yl)-1-phosphono-ethyl]...)
Affinity DataIC50: 1.10nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422449(CHEMBL101886)
Affinity DataIC50: 1.30nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422469(CHEMBL101472)
Affinity DataIC50: 1.40nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422457(CHEMBL101230)
Affinity DataIC50: 1.70nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422470(CHEMBL100508)
Affinity DataIC50: 1.80nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422463(CHEMBL101207)
Affinity DataIC50: 2nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal His-tagged human FPPS (1 to 353 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50117257({1-Hydroxy-3-[methyl-(3-phenyl-propyl)-amino]-1-ph...)
Affinity DataIC50: 2.60nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422455(CHEMBL98476)
Affinity DataIC50: 2.70nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50135839([1-Hydroxy-3-(4-phenyl-butylamino)-1-phosphono-pro...)
Affinity DataIC50: 2.70nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422454(CHEMBL316913)
Affinity DataIC50: 2.80nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 3nMAssay Description:Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FDPS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FDPS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422446(CHEMBL101407)
Affinity DataIC50: 3.10nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50135831([1-Hydroxy-3-(3-phenoxy-propylamino)-1-phosphono-p...)
Affinity DataIC50: 3.30nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50422448(CHEMBL100441)
Affinity DataIC50: 3.90nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50117260(1-hydroxy-3-(methyl(phenethyl)amino)propane-1,1-di...)
Affinity DataIC50: 3.90nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM12576(JMC515594 Compound 64 | Risdronate | CHEMBL923 | R...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant FPP synthase expressed in Escherichia coli S100 using FPP and IPP as substrates preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
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