Compile Data Set for Download or QSAR
Report error Found 1091 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase CBL-B'
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570682(CHEMBL4846771)
Affinity DataKd:  2.44E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570683(CHEMBL4853735)
Affinity DataKd:  2.24E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570684(CHEMBL4872230)
Affinity DataKd:  5.55E+3nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570686(CHEMBL4865503)
Affinity DataKd:  9.83E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570688(CHEMBL4858812)
Affinity DataKd:  5.71E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570689(CHEMBL4867045)
Affinity DataKd:  2.44E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570690(CHEMBL4874562)
Affinity DataKd:  1.85E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570691(CHEMBL4869894)
Affinity DataKd:  8.28E+3nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570692(CHEMBL4870377)
Affinity DataKd:  763nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570693(CHEMBL4875389)
Affinity DataKd:  2.98E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570694(CHEMBL4870845)
Affinity DataKd:  3.55E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570695(CHEMBL4850928)
Affinity DataKd:  4.34E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570696(CHEMBL4866454)
Affinity DataKd:  2.29E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50570697(CHEMBL4850791)
Affinity DataKd:  3.35E+4nMAssay Description:Binding affinity to recombinant His-tagged Cbl-b (unknown origin) (39 to 368 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50634564(CHEMBL205371)
Affinity DataKd:  400nMAssay Description:Binding affinity to avidin-biotinylated Cbl-b at (36 to 427 residues) (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50634588(CHEMBL5421689)
Affinity DataKd:  3nMAssay Description:Binding affinity to avidin-biotinylated Cbl-b at (36 to 427 residues) (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50634584(CHEMBL5408828)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of Cbl-b in cryo-preserved human CD3-positive T cells assessed as increase in IL-2 production preincubated for 1 hr followed by alpha-CD3 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50634585(CHEMBL5410941)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of Cbl-b in cryo-preserved human CD3-positive T cells assessed as increase in IL-2 production preincubated for 1 hr followed by alpha-CD3 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50634586(CHEMBL5400157)
Affinity DataEC50:  2.61E+3nMAssay Description:Inhibition of Cbl-b in cryo-preserved human CD3-positive T cells assessed as increase in IL-2 production preincubated for 1 hr followed by alpha-CD3 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50634587(CHEMBL5403280)
Affinity DataEC50:  1.65E+3nMAssay Description:Inhibition of Cbl-b in cryo-preserved human CD3-positive T cells assessed as increase in IL-2 production preincubated for 1 hr followed by alpha-CD3 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataEC50:  410nMAssay Description:Inhibition of Cbl-b in cryo-preserved human CD3-positive T cells assessed as increase in IL-2 production preincubated for 1 hr followed by alpha-CD3 ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710620((S)-2-(3-(cyclobutyl(hydroxy)(4-methyl-4H- 1,2,4-t...)
Affinity DataKd:  2.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710657(2-(6-(ethylamino)-4-(6-(4-methyl-4H-1,2,4- triazol...)
Affinity DataKd:  1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710658(2-(6-(cyclopentylamino)-4-((1s,3s)-3- methoxy-1-(4...)
Affinity DataKd:  3.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710659(2-(6-(cyclopentylamino)-4-((1r,3r)-3- methoxy-1-(4...)
Affinity DataKd:  11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710662(6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataKd:  2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710663(6-(((S)-2-isorpopyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataKd:  120nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710664(6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataKd:  630nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710665(6-(((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl...)
Affinity DataKd:  770nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710666(2-(6-cyclopropyl-4-(3,3-difluoro-1-(4- methyl-4H-1...)
Affinity DataKd:  0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710667(2-(4-(3,3-difluoro-1-(4-methyl-4H-1,2,4- triazol-3...)
Affinity DataKd:  0.370nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710668(2-(3-(1-(4-methyl-4H-1,2,4-triazol-3-yl)-3- methyl...)
Affinity DataKd:  1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710669(2-(3-(1-(4-methyl-4H-1,2,4-triazol-3-yl)-3- oxocyc...)
Affinity DataKd:  40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710670(2-(3-((1r,3r)-3-hydroxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710671(2-(3-((1s,3s)-3-hydroxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  4.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710672(2-(3-((1s,3s)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  2.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710673(2-(3-((1r,3r)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  2.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710674((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3-yl)-3- (3-(...)
Affinity DataKd:  1.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710675((1s,3s)-3-(4-methyl-4H-1,2,4-triazol-3-yl)- 3-(3-(...)
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710676(2-(3-((1s,3s)-3-hydroxy-3-methyl-1-(4- methyl-4H-1...)
Affinity DataKd:  10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710677((2-(3-((1r,3r)-3-hydroxy-3-methyl-1-(4- methyl-4H-...)
Affinity DataKd:  60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710678(2-(3-((1r,3r)-3-methoxy-3-methyl-1-(4- methyl-4H-1...)
Affinity DataKd:  2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710679((2-(3-((1s,3s)-3-hydroxy-3-methyl-1-(4- methyl-4H-...)
Affinity DataKd:  59nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710680(2-(3-((1s,3s)-3-fluoro-3-methyl-1-(4- methyl-4H-1,...)
Affinity DataKd:  2.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710681(2-(3-((1r,3r)-3-fluoro-3-methyl-1-(4-methyl- 4H-1,...)
Affinity DataKd:  2.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710684(2-(3-((1s,3s)-3-methyl-1-(4-methyl-4H- 1,2,4-triaz...)
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710685(2-(3-((1r,3r)-3-methyl-1-(4-methyl-4H- 1,2,4-triaz...)
Affinity DataKd:  0.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710686(2-(3-((1r,3r)-3-fluoro-1-(4-methyl-4H-1,2,4- triaz...)
Affinity DataKd:  1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710687((S)-6-(1-(cyclobutylamino)ethyl)-2-(3-(3,3- difluo...)
Affinity DataKd:  0.800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM710688((R)-6-(1-(cyclobutylamino)ethyl)-2-(3-(3,3- difluo...)
Affinity DataKd:  3.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

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