Compile Data Set for Download or QSAR
Report error Found 1963 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1'
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  520nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKd:  1.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  1.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  360nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  1.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  77nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  21nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  130nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  1.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  1.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM50194066(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-3...)
Affinity DataEC50:  605nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194025(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  43nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194019(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Affinity DataEC50:  444nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50187841(3-hydroxy-5-(4-iodo-2-methylphenylamino)-N-isoprop...)
Affinity DataEC50:  1.48E+3nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194041(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  75nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194050(5-4-benzylphenylamino)-3-hydroxy-N-1-hydroxypropan...)
Affinity DataEC50:  130nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194055(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Affinity DataEC50:  54nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194063(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  49nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194017(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataEC50:  564nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194062(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylthio)p...)
Affinity DataEC50:  650nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194028(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  47nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194026(5-4-2,5-dichlorophenoxy)phenylamino)-N-3,4-dihydro...)
Affinity DataEC50:  22nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194045(5-4-2,5-dichlorophenoxy)phenylamino)-N-1,3-dihydro...)
Affinity DataEC50:  120nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataEC50:  42nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50187848(5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxy...)
Affinity DataEC50:  375nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194047(5-4-benzoylphenylamino)-3-hydroxy-N-1-hydroxypropa...)
Affinity DataEC50:  100nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50196392(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylamino)...)
Affinity DataEC50:  45nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194023(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-t...)
Affinity DataEC50:  65nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194043(5-3-chloro-4-iodophenylamino)-3-hydroxy-N-isopropy...)
Affinity DataEC50:  6.19E+3nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194037(5-4-2-chloro-4-fluorophenoxy)phenylamino)-3-hydrox...)
Affinity DataEC50:  250nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194061(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataEC50:  130nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194022(5-4-2-fluoro-5-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataEC50:  330nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194059(5-4-2-chloro-3-trifluoromethyl)phenoxy)-3-fluoroph...)
Affinity DataEC50:  88nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194064(5-3-chloro-4-2-chloro-3-trifluoromethyl)phenoxy)ph...)
Affinity DataEC50:  70nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194049(5-4-3-dimethylamino)phenoxy)phenylamino)-3-hydroxy...)
Affinity DataEC50:  130nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194067(5-4-3-fluoro-5-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataEC50:  30nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194052(5-4-2-chloro-5-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataEC50:  350nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194056(5-3-chloro-4-2,3-dichlorophenoxy)phenylamino)-3-hy...)
Affinity DataEC50: >10nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194057(5-4-2,4-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataEC50:  140nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194027(5-3-chloro-4-2-chloro-4-fluorophenoxy)phenylamino)...)
Affinity DataEC50:  37nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194054(5-4-2,4-difluorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataEC50:  150nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194060(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-3...)
Affinity DataEC50:  284nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194034(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  35nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194042(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  118nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194031(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-4...)
Affinity DataEC50:  113nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194039(5-4-2-chloro-3,5-difluorophenoxy)-3-fluorophenylam...)
Affinity DataEC50:  332nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194065(5-4-2-chloro-3,5-difluorophenoxy)phenylamino)-3-hy...)
Affinity DataEC50:  78nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194051(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-m...)
Affinity DataEC50:  47nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50194033(5-4-2-chloro-4-fluorophenoxy)-2-methylphenylamino)...)
Affinity DataEC50:  250nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to MEK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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