Compile Data Set for Download or QSAR
Report error Found 3131 Enz. Inhib. hit(s) with Target = 'Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B'
LigandPNGBDBM289541(8-((1,4-Oxazepan-4-yl)methyl)-6-(4-methoxybenzyl)t...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289543(6-(4-Methoxybenzyl)-8-(morpholinomethyl)thieno[3,2...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289545(8-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289546(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289547(6-(4-Methoxybenzyl)-8-((4-(methylsulfonyl)piperazi...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289548(8-(2,2-Dimethylmorpholino)methyl)-6-(4-methoxybenz...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289549(8-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-6-(...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289550(8-(7-Oxa-2-azaspiro[3.5]nonan-2-ylmethyl)-6-(4-met...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289551(8-(2-Oxa-7-azaspiro[3.5]nonan-7-ylmethyl)-6-(4-met...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289552(7-((6-(4-Methoxybenzyl)-5-oxo-5,6-dihydrothieno[3,...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289553(6-(4-Methoxybenzyl)-8-(1-methyl-3-(trifluoromethyl...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289556(6-(4-Methoxybenzyl)-9-methyl-8-(morpholinomethyl)t...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289557(8-((Dimethylamino)methyl)-6-(4-methoxybenzyl)-9-me...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289558(8-((Cyclopropyl(methyl)amino)methyl)-6-(4-methoxyb...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289559(8-((4-Hydroxypiperidin-1-yl)methyl)-6-(4-methoxybe...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289560(8-((Benzyl(2-hydroxyethyl)amino)methyl)-6-(4-metho...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289562(6-(4-Methoxybenzyl)-9-methyl-8-((((3-methyloxetan-...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289563(8-((4-Acetylpiperazin-1-yl)methyl)-6-(4-methoxyben...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289564(6-(4-Methoxybenzyl)-9-methyl-8-(((pyridin-3-ylmeth...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289565(6-(4-Methoxybenzyl)-9-methyl-8-((3-oxopiperazin-1-...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289566(6-(4-Methoxybenzyl)-9-methyl-8-((methyl((tetrahydr...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289567(8-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289568(8-(Isoindolin-2-ylmethyl)-6-(4-methoxybenzyl)-9-me...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289569(8-((Cyclopropylamino)methyl)-6-(4-methoxybenzyl)-9...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289570((S)-6-(4-Methoxybenzyl)-8-((2-(methoxymethyl)pyrro...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289571(6-(4-Methoxybenzyl)-9-methyl-8-((methyl((tetrahydr...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289572(2-(((6-(4-Methoxybenzyl)-9-methyl-5-oxo-5,6-dihydr...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289573(8-((1,4-Oxazepan-4-yl)methyl)-6-(4-methoxybenzyl)-...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289574(6-(4-Methoxybenzyl)-9-methyl-8-((4-methylpiperazin...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289575(6-(4-Methoxybenzyl)-9-methyl-8-((4-(methylsulfonyl...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289576(8-((4-Isopropylpiperazin-1-yl)methyl)-6-(4-methoxy...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289577(8-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-6-(...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289578(8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289579(8-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-6-(4...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289580(8-((2-Ethylmorpholino)methyl)-6-(4-methoxybenzyl)-...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289581(8-((2,2-Dimethylmorpholino)methyl)-6-(4-methoxyben...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289582(6-(4-Methoxybenzyl)-9-methyl-8-((2-methylmorpholin...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289583(6-(4-Methoxybenzyl)-9-methyl-8-((3-methylmorpholin...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289585(8-((3,4-Dimethylpiperazin-1-yl)methyl)-6-(4-methox...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289586(6-(4-Methoxybenzyl)-9-methyl-8-((3,3,4-trimethylpi...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289587((S)-8-((Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)me...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289592(tert-Butyl 6-(4-methoxybenzyl)-5-oxo-5,6,10,11-tet...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289602(6-(4-Methoxybenzyl)-6,8,10,11-tetrahydro-5H-pyrano...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289615(6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289616(2-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-4-(4-me...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289617(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289618(6-(4-Chlorobenzyl)-9-(oxetan-3-yl)-8,9,10,11-tetra...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289620(6-(4-Methoxybenzyl)-9-((5-methyl-1,3,4-thiadiazol-...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM289622(9-(Cyclopropylmethyl)-6-(4-methoxybenzyl)-8,9,10,1...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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