Compile Data Set for Download or QSAR
Report error Found 2726 Enz. Inhib. hit(s) with Target = 'Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A'
LigandPNGBDBM50537770(CHEMBL4642086)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50537772(CHEMBL4633023)
Affinity DataKd:  16nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50537785(CHEMBL4645801)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50537792(CHEMBL4638576)
Affinity DataKd:  16nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50537798(CHEMBL4637690)
Affinity DataKd:  6.80nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50537803(CHEMBL4633227)
Affinity DataKd:  68nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50537806(CHEMBL4643091)
Affinity DataKd:  46nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataKd:  14nMAssay Description:Binding affinity to PDE1A (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM501502(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[1- methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM580557(US11491140, Example 132 | 5-(2-ethoxy-3-pyridyl)-3...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM528351(US11180503, Example 9 | 9-([1,1'- Bi(cyclopropan)]...)
Affinity DataIC50: 0.214nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM501512(1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)me...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM528352(US11180503, Example 10 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 0.260nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM528349(US11180503, Example 7 | 9-([1,1'- Bi(cyclopropan)]...)
Affinity DataIC50: 0.343nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM501501(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM580556(US11491140, Example 131 | 5-(2-ethoxy-3-pyridyl)-3...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM528331(US11180503, Example 1 | 9-([1,1'-bi(cyclopropan)]-...)
Affinity DataIC50: 0.366nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279017(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM278972(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 0.460nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM278972(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 0.460nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM278972(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 0.460nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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