Compile Data Set for Download or QSAR
Report error Found 86 Enz. Inhib. hit(s) with Target = 'Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q]'
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  0.0600nM ΔG°:  -57.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26524((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...)
Affinity DataKi:  0.140nM ΔG°:  -55.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26525((1S,2R)-1-N-hydroxy-2-({4-[(2-phenylquinolin-4-yl)...)
Affinity DataKi:  0.180nM ΔG°:  -55.1kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23489((1R,2S)-2-N-hydroxy-1-N,1-N-dimethyl-1-({4-[(2-met...)
Affinity DataKi:  1nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26555(2-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}ethane-...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  3nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23487((1S,2R)-1-N-hydroxy-2-({4-[(2-methylquinolin-4-yl)...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26556(3-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}propane...)
Affinity DataKi:  4.5nM ΔG°:  -47.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23477((1R,2R)-2-N-hydroxy-1-{3-[(2-methylquinolin-4-yl)m...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26549((3R)-1-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}py...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26527((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  6.70nM ΔG°:  -46.2kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23458(propan-2-yl (1R,2R)-2-(hydroxycarbamoyl)-1-{3-[(2-...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26553(2-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}ethane-1-...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23484(CHEMBL410462 | methyl (1R,2S)-2-(hydroxycarbamoyl)...)
Affinity DataKi:  8nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23482((1R,2R)-1-N-cyclohexyl-2-N-hydroxy-1-{3-[(2-methyl...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26554(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}propane-1...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23480((1R,2R)-2-N-hydroxy-1-{3-[(2-methylquinolin-4-yl)m...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26548(1-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}azetidi...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23456(methyl (1R,2R)-1-{3-[(3,4-dichlorophenyl)methoxy]p...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23454(CHEMBL270558 | methyl (1R,2R)-2-(hydroxycarbamoyl)...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26542(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}azetidine...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23488((1R,2S)-2-N-hydroxy-1-N-methyl-1-({4-[(2-methylqui...)
Affinity DataKi:  14nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23476(ethyl (1R,2R)-2-(hydroxycarbamoyl)-1-{3-[(2-methyl...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26559(3-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}cyclohe...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23464(methyl (1R,2R)-2-(hydroxycarbamoyl)-1-(3-{[4-(trif...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26552(4-(but-2-yn-1-yloxy)-N-methyl-N-[(2S)-2-sulfanylpr...)
Affinity DataKi:  27nM ΔG°:  -42.8kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26543((3R)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26543((3R)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26528((1S,3R)-N-hydroxy-4-oxo-6-{4-[(2-phenylquinolin-4-...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26558(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}cyclohexa...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26530((1S,3R)-N-hydroxy-6-{4-[(2-methylquinolin-4-yl)met...)
Affinity DataKi:  32nM ΔG°:  -42.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26529((1S,3R)-N-hydroxy-4-oxo-6-(4-{[2-(pyridin-3-yl)qui...)
Affinity DataKi:  32nM ΔG°:  -42.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26531((1S,3R)-N-hydroxy-4-oxo-6-(4-{[2-(pyridin-4-yl)qui...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26544((3S)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26534((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  40nM ΔG°:  -41.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23470(methyl (1R,2R)-1-[3-(2-{3-[(1Z)-buta-1,3-dien-1-yl...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23465(methyl (1R,2R)-1-{3-[(4-chlorophenyl)methoxy]pheny...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26557(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}cyclopent...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26532((1S,3R)-N-hydroxy-4-oxo-6-(4-{[2-(trifluoromethyl)...)
Affinity DataKi:  53nM ΔG°:  -41.1kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26545(Racemic | 1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl...)
Affinity DataKi:  55nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  56nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23469(methyl (1R,2R)-2-(hydroxycarbamoyl)-1-{3-[2-(napht...)
Affinity DataKi:  60nM ΔG°:  -40.8kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23463(methyl (1R,2R)-2-(hydroxycarbamoyl)-1-(3-{[3-(trif...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23471(methyl (1R,2R)-2-(hydroxycarbamoyl)-1-[3-(naphthal...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23497((1R,2S)-1-{[4-(but-2-yn-1-yloxy)phenyl]methyl}-2-N...)
Affinity DataKi:  80nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM23466(methyl (1R,2R)-1-{3-[(3-fluorophenyl)methoxy]pheny...)
Affinity DataKi:  80nM ΔG°:  -40.1kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26535((1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  94nM ΔG°:  -39.7kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23478((1R,2R)-2-N-hydroxy-1-N-methyl-1-{3-[(2-methylquin...)
Affinity DataKi:  100nM ΔG°:  -39.6kJ/molepH: 7.3 T: 2°CAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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