Compile Data Set for Download or QSAR
Report error Found 895 Enz. Inhib. hit(s) with Target = 'Dimer of Protein farnesyltransferase subunit beta'
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143596(30-oxo-(1R,5R)-19-oxa-2,6,10,12-tetraazahexacyclo[...)
Affinity DataEC50:  0.180nMAssay Description:Effective concentration required to inhibit HDJ2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153168(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153170(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143599(4-[(S)-1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181249(5-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(nap...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181245(3-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(nap...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153169(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against Farnesyltransferase quantified by modified SPA assay with improved sensitivityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081221(4-{5-[(S)-2-Butyl-4-(3-chloro-phenyl)-5-oxo-pipera...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081212(4-{5-[(S)-2-Butyl-5-oxo-4-(3-trifluoromethyl-pheno...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369443(CHEMBL252953)
Affinity DataIC50: 0.150nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181261(3-(3-(1H-imidazol-1-yl)propyl)-1-(4-bromobenzyl)-5...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081215(4-{5-[(S)-4-(3-Chloro-phenyl)-2-ethanesulfonylmeth...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181255(4-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(nap...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181252(3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(methylthiomet...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181239(3-(3-(1H-imidazol-1-yl)propyl)-1-(3-chlorobenzyl)-...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153173(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153164(N-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-N-(5...)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155778(1-[4-((S)-3,10-Dibromo-8-chloro-11H-benzo[5,6]cycl...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of [3H]FPP incorporation into H-ras CVLS by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181248(N-(4-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153176(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048982((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propi...)
Affinity DataIC50: 0.370nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153166(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126041(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153172(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181258(3-(3-(1H-imidazol-1-yl)propyl)-1-(3-bromobenzyl)-5...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155775(4-{2-[4-((S)-3,10-Dibromo-8-chloro-11H-benzo[5,6]c...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]FPP incorporation into H-ras CVLS by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081217(4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-5-oxo-pi...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048970((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50: 0.460nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153175(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067584(2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bipheny...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of mammalian protein farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181246(N-(2-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16179(4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrr...)
Affinity DataIC50: 0.520nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048963((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50: 0.570nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048972((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153171(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067584(2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bipheny...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067584(2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bipheny...)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153174(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181240(3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(methylthio)be...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181235(3-(3-(1H-imidazol-1-yl)propyl)-1-(3-phenoxybenzyl)...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126036(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant Ras CVIM by human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181247(5-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(nap...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048967((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Affinity DataIC50: 0.75nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181242(3-(3-(1H-imidazol-1-yl)propyl)-1-(4-phenoxybenzyl)...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048399((S)-2-[((S)-2-{(S)-2-[2-(3H-Imidazol-4-yl)-ethylam...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079090([(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079085(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against Hras Farnesyltransferase (FPT).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181259((2S)-2-(2-(3-(3-(1H-imidazol-5-yl)propyl)-5-methyl...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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