Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with Target = 'Dimer of Gag-Pol polyprotein [514-612]'
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1250((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)
Affinity DataIC50: 6.30nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1249((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)
Affinity DataIC50: 6.70nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1248((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)
Affinity DataIC50: 38nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1247((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)
Affinity DataIC50: 42nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1252((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)
Affinity DataIC50: 135nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM1251((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)
Affinity DataIC50: 185nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM729(CHEMBL13134 | BILA 2011 BS | (2S,4R)-N-tert-butyl-...)
Affinity DataKi:  0.130nM ΔG°:  -58.7kJ/mole IC50: 10nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM517(Crixivan | CHEMBL115 | L-735, 524 | MK639 | Indina...)
Affinity DataKi:  3.32nM ΔG°:  -49.2kJ/molepH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM870(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  16nM ΔG°:  -46.3kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM966(benzyl N-[(1S)-1-{[(2S,3R,4R)-4-{[(1S)-1-[(1H-1,3-...)
Affinity DataKi:  17nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM857(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  19nM ΔG°:  -45.8kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM858(benzyl N-[(1S)-1-{[(1S,2S)-1-[(13R,16R)-12,15-diox...)
Affinity DataKi:  27nM ΔG°:  -44.9kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM770(4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl...)
Affinity DataKi:  32nMAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM936(benzyl N-[(1S)-1-{[(2S,3R,4R)-4-{[(1S)-1-(benzylca...)
Affinity DataKi:  39nM ΔG°:  -44.0kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM875(benzyl N-[(1S)-1-{[(2S,3S,4R)-3-hydroxy-4-{[(1S,2S...)
Affinity DataKi:  50nM ΔG°:  -43.3kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
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PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM967(5PhBuCOOH deriv. | Tle-Val-Sta | benzyl N-[(1S)-1-...)
Affinity DataKi:  52nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM942(5PhBuCOOH deriv. | benzyl N-[(1S)-1-{[(2S,3R,4R)-4...)
Affinity DataKi:  54nM ΔG°:  -43.2kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM968(5PhBuCOOH deriv. | (2R,3R,4S)-N-[(1S)-1-[(1H-1,3-b...)
Affinity DataKi:  63nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM969(5PhBuCOOH deriv. | (2R,3R,4S)-N-[(1S)-1-[(1H-1,3-b...)
Affinity DataKi:  110nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM964(2-Aminobenzyl-Substituted AHPPA deriv. 1 | 5PhBuCO...)
Affinity DataKi:  120nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM874(benzyl N-[(1S)-1-{[(2S,3S,4R)-4-{[(1R)-1-[(1H-1,3-...)
Affinity DataKi:  120nM ΔG°:  -41.1kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Boehringer Ingelheim (Canada)

LigandPNGBDBM926(5PhBuCOOH deriv. | benzyl N-[(1S)-1-{[(2S,3R,4R)-4...)
Affinity DataKi:  180nM ΔG°:  -40.0kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed