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Report error Found 2529 Enz. Inhib. hit(s) with Target = 'Diacylglycerol kinase zeta'
TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644197(US11866430, Example 120)
Affinity DataIC50: 0nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644200(US11866430, Example 123)
Affinity DataIC50: 0nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM692721(2-(7-((2S,5R)-5-ethyl-2-methyl-4-(1-(quinoxalin-6-...)
Affinity DataIC50: 1nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668707(US11964953, Example 48.1)
Affinity DataIC50: 1.76nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668705(US11964953, Example 47.2)
Affinity DataIC50: 1.96nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594321(US11584747, Example 116 | US11584747, Example 117)
Affinity DataIC50: 2nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668880(US11964953, Example 165.1)
Affinity DataIC50: 2nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668883(US11964953, Example 166.1)
Affinity DataIC50: 2nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668885(US11964953, Example 167)
Affinity DataIC50: 2nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644152(US11866430, Example 40 | US20240108654, Compound 1...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human DGK zeta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668711(US11964953, Example 49.2)
Affinity DataIC50: 2.10nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668823(US11964953, Example 119 | US11964953, Example 145)
Affinity DataIC50: 2.66nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668709(US11964953, Example 49)
Affinity DataIC50: 2.76nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM692676(2-(7-((2S,5R)-2,5-diethyl-4-(1- (isoquinolin-3-yl)...)
Affinity DataIC50: 2.80nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668879(US11964953, Example 165)
Affinity DataIC50: 3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668882(US11964953, Example 166)
Affinity DataIC50: 3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668886(US11964953, Example 167.1)
Affinity DataIC50: 3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668889(US11964953, Example 169)
Affinity DataIC50: 3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668890(US11964953, Example 169.1)
Affinity DataIC50: 3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM669003(US11964953, Example 268)
Affinity DataIC50: 3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668706(US11964953, Example 48)
Affinity DataIC50: 3.72nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668703(US11964953, Example 47)
Affinity DataIC50: 3.77nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594236(US11584747, Example 30 | US11584747, Example 31)
Affinity DataIC50: 4nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594506(US11584747, Example 313 | US11584747, Example 314)
Affinity DataIC50: 4nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668739(US11964953, Example 59.2 | US11964953, Example 59....)
Affinity DataIC50: 4nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668823(US11964953, Example 119 | US11964953, Example 145)
Affinity DataIC50: 4.54nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668874(US11964953, Example 163.1)
Affinity DataIC50: 5nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668877(US11964953, Example 164.1)
Affinity DataIC50: 5nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668893(US11964953, Example 170.1)
Affinity DataIC50: 5nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668702(US11964953, Example 46.2)
Affinity DataIC50: 5.69nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM692771(2-(7-((2S,5R)-4-(1-(2,4- difluorophenyl)ethyl)-2,5...)
Affinity DataIC50: 5.90nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668691(US11964953, Example 43.2)
Affinity DataIC50: 5.93nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594504(US11584747, Example 311 | US11584747, Example 312)
Affinity DataIC50: 6nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668726(US11964953, Example 55.1)
Affinity DataIC50: 6nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668997(US11964953, Example 262)
Affinity DataIC50: 6nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM693051(2-(7-((2S,5R)-4-(1-(3,3-dimethyl-2,3-dihydrofuro[3...)
Affinity DataIC50: 6nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668809(US11964953, Example 105)
Affinity DataIC50: 6.45nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM692635(US20240270751, Compound A28 | US20240270751, Compo...)
Affinity DataIC50: 6.70nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668862(US11964953, Example 158 | rac-2-(N-[4-amino-5-(4-b...)
Affinity DataIC50: 6.71nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668694(US11964953, Example 44.2)
Affinity DataIC50: 6.72nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668876(US11964953, Example 164)
Affinity DataIC50: 7nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668862(US11964953, Example 158 | rac-2-(N-[4-amino-5-(4-b...)
Affinity DataIC50: 7nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM693017(2-(7-((2S,5R)-4-(1-(3H-spiro[benzo[b][1,4]dioxine-...)
Affinity DataIC50: 7nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668700(US11964953, Example 46 | US11964953, Example 46.1)
Affinity DataIC50: 7.07nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668684(US11964953, Example 40.2)
Affinity DataIC50: 7.08nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM692763(2-(7-((2S,5R)-4-(1-(2,3-dihydrobenzo[b][1,4]dioxin...)
Affinity DataIC50: 7.20nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668680(US11964953, Example 38.2)
Affinity DataIC50: 7.37nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM692636(US20240270751, Compound A28a)
Affinity DataIC50: 7.60nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM692801(US20240270751, Compound A155b)
Affinity DataIC50: 7.60nMAssay Description:The inhibition activities testing for the compound disclosed herein were carried out at room temperature in assay buffer containing 50 mM HEPES, 10 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM668687(US11964953, Example 41.2)
Affinity DataIC50: 7.73nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in dimethyl sulfoxide (DMSO, Sigma) was pipetted into either a white 153...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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