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Report error Found 94 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-beta'
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449890(CHEMBL4161876)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449891(CHEMBL4174756)
Affinity DataIC50: 13nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50410828(CHEMBL5266387)
Affinity DataIC50: 26nMAssay Description:Inhibition of human DNA topoisomerase 2-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50520631(Ametantrone)
Affinity DataIC50: 30nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449889(CHEMBL4160802)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449888(CHEMBL4172196)
Affinity DataIC50: 81nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50449887(CHEMBL4169404)
Affinity DataIC50: 110nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50547613(CHEMBL4751362)
Affinity DataIC50: 130nMAssay Description:Inhibition of Topoisomerase II beta (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473499(BAY-507950 | CHEMBL156813)
Affinity DataIC50: 326nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229974(CHEMBL178077)
Affinity DataIC50: 452nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473499(BAY-507950 | CHEMBL156813)
Affinity DataIC50: 489nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50623278(CHEMBL5408150)
Affinity DataIC50: 550nMAssay Description:Inhibition of human DNA topoisomerase 2 beta assessed as relaxation of supercoiled plasmid pBR322 DNA incubated for 30 mins by ethidium bromide stain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50458474(CHEMBL4213218)
Affinity DataIC50: 580nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 603nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473497(BAY-507952 | CHEMBL157769)
Affinity DataIC50: 625nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229967(CHEMBL263944)
Affinity DataIC50: 666nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 727nMAssay Description:Inhibition of Topoisomerase II beta (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229969(CHEMBL554645)
Affinity DataIC50: 727nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50473497(BAY-507952 | CHEMBL157769)
Affinity DataIC50: 781nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 790nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229970(CHEMBL367876)
Affinity DataIC50: 796nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50458475(CHEMBL4205327)
Affinity DataIC50: 860nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 905nMAssay Description:Gyrase inhibitory activity against Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229972(CHEMBL174721)
Affinity DataIC50: 929nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50286486(5-Cyclopropyl-2-(2-dimethylamino-ethyl)-7-(2,6-dim...)
Affinity DataEC50:  930nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50520632(CHEMBL4553471)
Affinity DataIC50: 1.06E+3nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50520634(CHEMBL4575796)
Affinity DataIC50: 1.15E+3nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50286495(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229966(DESMETHYL-OFLOXACIN | Desmethyl-Ofloxacin (5%))
Affinity DataIC50: 1.69E+3nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataKi:  2.49E+3nMAssay Description:Inhibition constant against DNA Gyrase isolated from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50229965(CHEMBL174892)
Affinity DataIC50: 2.58E+3nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50227628(CHEMBL47311)
Affinity DataIC50: 2.67E+3nMAssay Description:Gyrase inhibitory activity against Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM87351(m-AMSA | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]...)
Affinity DataIC50: 2.76E+3nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 2.76E+3nMAssay Description:Gyrase inhibitory activity against Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50045004(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-ox...)
Affinity DataIC50: 2.76E+3nMAssay Description:Gyrase inhibitory activity against Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50586362(CHEMBL5083245)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human TOP2B assessed as reduction in relaxation of supercoiled DNA using kDNA as substrate incubated for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50045000(CHEMBL9 | (norfloxacin)1-Ethyl-6-fluoro-4-oxo-7-pi...)
Affinity DataKi:  3.13E+3nMAssay Description:Inhibition constant against DNA Gyrase isolated from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.18E+3nMAssay Description:Binding affinity to human TOP2B incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human topoisomerase 2beta after 2 hrs at 37 degC by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50520633(CHEMBL4448353)
Affinity DataIC50: 4.34E+3nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50045004(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-ox...)
Affinity DataKi:  4.42E+3nMAssay Description:Inhibition constant against DNA Gyrase isolated from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50520636(CHEMBL4467805)
Affinity DataIC50: 5.25E+3nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50474309(CHEMBL331076)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition effect on Escherichia coli Wild Type DNA gyrase Supercoiling activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50464488(CHEMBL4278922)
Affinity DataIC50: 9.29E+3nMAssay Description:Inhibition of human topoisomerase 2beta after 2 hrs at 37 degC by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50624746(CHEMBL5399261)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM87351(m-AMSA | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
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