Compile Data Set for Download or QSAR
Report error Found 59 Enz. Inhib. hit(s) with Target = 'DNA polymerase lambda'
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104089((Z)-5-(3-Nitro-4-(o-tolylthio)benzylidene)-2-thiox...)
Affinity DataIC50: 3.90E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104093((Z)-5-(3-Bromo-4-((3-fluoro-4-methylphenyl)thio)be...)
Affinity DataIC50: 4.00E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104097((Z)-5-(2,4-Bis(p-tolylthio)benzylidene)-2-thioxoth...)
Affinity DataIC50: 4.00E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198194(CHEMBL3978947)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50190131(Oblongifolin C)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50448068(Guttiferone K)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198198(CHEMBL3889506)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104079((Z)-5-(3-Chloro-4-(p-tolylthio)benzylidene)-2-thio...)
Affinity DataIC50: 5.70E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198200(CHEMBL3976184)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198195(CHEMBL3917534)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104067(DNA polymerase inhibitor 1)
Affinity DataIC50: 5.90E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
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PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104088((Z)-5-(3-Nitro-4-(m-tolylthio)benzylidene)-2-thiox...)
Affinity DataIC50: 6.00E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198197(CHEMBL3907489)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198196(CHEMBL3898463)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50356642(CHEMBL1917196)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198193(CHEMBL3926514)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50198199(CHEMBL3935433)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104096((Z)-2-Thioxo-5-(4-(o-tolylthio)-3- (trifluoromethy...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104098((Z)-5-((4-Bromo-5-(p-tolylthio)thiophen-2-yl)methy...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104095((Z)-5-(3-Fluoro-4-(o-tolylthio)benzylidene)-2-thio...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104094(23 (Z)-2-Thioxo-5-(4-(o-tolylthio)benzylidene)thia...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104090((Z)-5-(4-((3,5-Dimethylphenyl)thio)-3-nitrobenzyli...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104091((Z)-5-(4-(Naphthalen-2-ylthio)-3-nitrobenzylidene)...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104087((Z)-5-(3-Nitro-4-((2,3,5,6-tetrafluoro-4-(trifluor...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104086((Z)-5-(4-((3-Fluoro-4-methylphenyl)thio)-3-nitrobe...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104084((Z)-5-(3-Nitro-4-((4-(trifluoromethyl)phenyl)thio)...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104083((Z)-5-(4-((4-Ethylphenyl)thio)-3-nitrobenzylidene)...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104082((Z)-5-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104081((Z)-2-Thioxo-5-(4-(p-tolylthio)-3- (trifluoromethy...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104080((Z)-5-(3-Bromo-4-(p-tolylthio)benzylidene)-2-thiox...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104078((Z)-5-(3-Fluoro-4-(p-tolylthio)benzylidene)-2-thio...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104077((Z)-2-Thioxo-5-(4-(p-tolylthio)benzylidene)thiazol...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104074((Z)-5-(1-(3-Nitro-4-(p-tolylthio)phenyl)ethylidene...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104069((Z)-5-(3-Nitro-4-(p-tolylthio)benzylidene)thiazoli...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104068((Z)-5-(4-(Cyclohexylthio)-3-nitrobenzylidene)-2-th...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50356643(CHEMBL1917198)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104076((Z)-5-(3-Nitro-4-tosylbenzylidene)-2-thioxothiazol...)
Affinity DataIC50: 2.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104085((Z)-5-(3-Nitro-4-((4-(trifluoromethoxy)phenyl)thio...)
Affinity DataIC50: 2.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104092((Z)-5-(4-(Cyclopentylthio)-3-nitrobenzylidene)-2-t...)
Affinity DataIC50: 2.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50020676(CHEMBL566812 | CHEBI:41846)
Affinity DataIC50: 2.87E+4nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50208251(3-5-dimethyl-8-methoxy-3,4-dihydroisocoumarin | CH...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of human DNA polymerase lambdaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50208247((3,4-dihydro-4-hydroxy-8-methoxynaphthalene-1(2H)-...)
Affinity DataIC50: 8.20E+4nMAssay Description:Inhibition of human DNA polymerase lambdaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50208248((1,2,3,4-tetrahydro-5-methoxynaphthalene-1,4-diol ...)
Affinity DataIC50: 1.68E+5nMAssay Description:Inhibition of human DNA polymerase lambdaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50208250(3-methyl-8-methoxy-3,4-dihydroisocoumarin | CHEMBL...)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human DNA polymerase lambdaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Mouse)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50448688(Pecilocin | Variotin)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of mouse DNA polymerase lambda assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as templa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase lambda(Mouse)
Kobe Gakuin University

Curated by ChEMBL
LigandPNGBDBM50448691(CHEMBL3127729)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of mouse DNA polymerase lambda assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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