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Report error Found 168 Enz. Inhib. hit(s) with Target = 'DNA polymerase alpha catalytic subunit'
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001141(CHEMBL3236417)
Affinity DataEC50:  3.50E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001142(CHEMBL3236418)
Affinity DataEC50:  8.00E+4nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001143(CHEMBL3236419)
Affinity DataEC50: >5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001204(CHEMBL3236420)
Affinity DataEC50: >5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001205(CHEMBL3236421)
Affinity DataEC50: >5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001206(CHEMBL3236422)
Affinity DataEC50:  2.50E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001207(CHEMBL3236423)
Affinity DataEC50: >5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001208(CHEMBL3236424)
Affinity DataEC50:  7.00E+4nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001209(CHEMBL3236425)
Affinity DataEC50:  4.10E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001210(CHEMBL3236426)
Affinity DataEC50: >5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042445(6-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahy...)
Affinity DataEC50:  4.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042448(7-Formyl-6-methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,1...)
Affinity DataEC50:  3.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042454(7-Formyl-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,1...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042449(1,7-Bis-hydroxymethyl-1,4a-dimethyl-1,2,3,4,4a,9,1...)
Affinity DataEC50:  4.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042459(1-Hydroxymethyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-...)
Affinity DataEC50:  8.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042447(1,7-Bis-hydroxymethyl-1,4a-dimethyl-1,2,3,4,4a,9,1...)
Affinity DataEC50:  7.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042444(6-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahy...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataEC50:  2.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50042456((8-Hydroxymethyl-3-methoxy-4b,8-dimethyl-4b,5,6,7,...)
Affinity DataEC50:  3.00E+3nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50231384(CHEMBL331025)
Affinity DataEC50: <1nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50231345(CHEMBL118970)
Affinity DataEC50: <1nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50231383(CHEMBL334229)
Affinity DataEC50: <1nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50231386(CHEMBL331553)
Affinity DataEC50: <1nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50231388(CHEMBL119211)
Affinity DataEC50: <1nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50231343(CHEMBL119038)
Affinity DataEC50: <1nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50231344(CHEMBL334214)
Affinity DataEC50: <1nMAssay Description:Effective concentration against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of DNA polymerase alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50408427(CHEMBL483492)
Affinity DataIC50: 15nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50408426(CHEMBL2092833)
Affinity DataIC50: 480nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50443277(CHEMBL5281189)
Affinity DataIC50: 680nMAssay Description:Inhibition of DNA polymerase alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50184755((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycar...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50184758((3aS,4S,7R,7aR)-1,6-didodecyl-2,7-bis(methoxycarbo...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50184757((3aR,4R,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50335554(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human DNA polymerase alpha by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 2.60E+3nMpH: 7.5Assay Description:Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 3.00E+3nMAssay Description:Compound was evaluated for the inhibitory activity against Human alpha polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50184752((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(isopropoxy...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human DNA polymerase-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50184756((3aR,4S,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50184754((E)-methyl-3,6-dioxo-4-docosenoate | CHEMBL425779)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50143526(Untenone A | CHEMBL366792)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50313783(N-(4-chlorobenzyl)-1-methyl-9-(morpholinomethyl)-2...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant DNA polymerase alpha expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50313784((R)-9-(((2-(benzofuran-2-yl)-2-hydroxyethyl)(methy...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant DNA polymerase alpha expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50184761((3aR,4R,7S,7aS)-dimethyl 3,5-dihexadecyl-1-oxo-7-(...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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