Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 3A4/3A43/3A5/3A7'
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50464556(CHEMBL4289811 | US10464907, Compound 21f | US10889...)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of CYP3A in human pooled human liver microsomes using midazolam as substrate assessed as midazolam 1'-hydroxylation preincubated for 5 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of CYP3A in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50527104(CHEMBL4447583)
Affinity DataIC50: 6.22E+4nMAssay Description:Inhibition of CYP3A in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50527104(CHEMBL4447583)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed