Compile Data Set for Download or QSAR
Report error Found 461 Enz. Inhib. hit(s) with Target = 'Cyclin-K/Cyclin-dependent kinase 12'
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479080((R)-N-(4-(3-((4-(methylamino)-5- (trifluoromethyl)...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479084(US10894788, Example 124 | (R)-N-(4-(3-((5-chloro-4...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479085((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479097((R)-N-(4-(3-((5-chloro-4-(2- hydroxyethoxy)pyrimid...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479007(US10894788, Example 47 | US10894788, Example 138 |...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479046(US10894788, Example 86 | US10894788, Example 139 |...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479103(N-(4-((R)-3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479104((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479111((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479112((R)-N-(6-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479084(US10894788, Example 124 | (R)-N-(4-(3-((5-chloro-4...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479117((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479122(N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479123(N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479124((R)-N-(4-(3-((5-cyano-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479126((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479128((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479139(N-(4-((2S,4R)-4-((5-chloro-4- methoxypyrimidin-2-y...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479140((R)-N-(4-(3-((5-ethynylpyrimidin-2- yl)amino)pyrro...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479141((R)-N-(4-(3-((5-ethynyl-4- methoxypyrimidin-2- yl)...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479142(N-(4-((2R,4R)-4-((5-chloro-4- methoxypyrimidin-2-y...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM479143(US10894788, Example 184Biochemical | US11390618, E...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572060((R)-N-(4-(3-((6-chloroquinazolin-2- yl)amino)pyrro...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572061((R)-N-(4-(3-(quinazolin-2- ylamino)pyrrolidine-1- ...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572061((R)-N-(4-(3-(quinazolin-2- ylamino)pyrrolidine-1- ...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the protein kinase. All kinase assays w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572062((R)-N-(4-(3-(isoquinolin-3- ylamino)pyrrolidine-1-...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572063((R)-N-(4-(3-((6-fluoroquinazolin-2- yl)amino)pyrro...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572063((R)-N-(4-(3-((6-fluoroquinazolin-2- yl)amino)pyrro...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the protein kinase. All kinase assays w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572066((R)-N-(4-(3-(pyrido[3,4-d]pyrimidin- 2-ylamino)pyr...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572067((R)-N-(4-(3-((7-methylquinazolin-2- yl)amino)pyrro...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572068((R)-N-(4-(3-((7- (methylsulfonyl)quinazolin-2- yl)...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572068((R)-N-(4-(3-((7- (methylsulfonyl)quinazolin-2- yl)...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the protein kinase. All kinase assays w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572069((R)-N-(4-(3-((7-methoxyquinazolin- 2-yl)amino)pyrr...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572069((R)-N-(4-(3-((7-methoxyquinazolin- 2-yl)amino)pyrr...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the protein kinase. All kinase assays w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572070((R)-N-(4-(3-((7-fluoroquinazolin-2- yl)amino)pyrro...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572072((R)-N-(4-(3-((7-cyanoquinazolin-2- yl)amino)pyrrol...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572072((R)-N-(4-(3-((7-cyanoquinazolin-2- yl)amino)pyrrol...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the protein kinase. All kinase assays w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572073((R)-2-((1-(4- acrylamidobenzoyl)pyrrolidin-3- yl)a...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572074((R)-2-((1-(4- acrylamidobenzoyl)pyrrolidin-3- yl)a...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572075(US11447493, Example 58 | (R)-2-((1-(4- acrylamidob...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572076((R)-2-((1-(4- acrylamidobenzoyl)pyrrolidin-3- yl)a...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572077((R)-N-(4-(3-((7-oxo-7,8- dihydropyrido[2,3-d]pyrim...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572078((R)-N-(4-(3-((8-isopropyl-7-oxo-7,8- dihydropyrido...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572078((R)-N-(4-(3-((8-isopropyl-7-oxo-7,8- dihydropyrido...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the protein kinase. All kinase assays w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572091((R)-2-((1-(4- propionamidobenzoyl)pyrrolidin-3- yl...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572092((R)-2-((1-(4- propionamidobenzoyl)pyrrolidin-3- yl...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572075(US11447493, Example 58 | (R)-2-((1-(4- acrylamidob...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572094((R)-N,N-dimethyl-2-((1-(4- propionamidobenzoyl)pyr...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM572095((R)-N-(4-(3-((7-oxo-7,8- dihydropyrido[2,3-d]pyrim...)
Affinity DataIC50: 100nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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