Compile Data Set for Download or QSAR
Report error Found 482 Enz. Inhib. hit(s) with Target = 'Cyclin-H/Cyclin-dependent kinase 7'
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50526790(CHEMBL4555799)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583916(CHEMBL4786320)
Affinity DataKd:  0.150nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583917(CHEMBL4800180)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583918(CHEMBL4791134)
Affinity DataKd:  0.0700nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583919(CHEMBL5083688)
Affinity DataKd:  0.0900nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583920(CHEMBL4786843)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583921(CHEMBL4779443)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583922(CHEMBL4786555)
Affinity DataKd:  0.210nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583923(CHEMBL4786592)
Affinity DataKd:  0.0800nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583924(CHEMBL4790490)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583925(CHEMBL4782954)
Affinity DataKd:  0.0800nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583926(CHEMBL4798916)
Affinity DataKd:  0.150nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583927(CHEMBL5088381)
Affinity DataKd:  0.0300nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583928(CHEMBL5080711)
Affinity DataKd:  0.0600nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583929(Sy 5609 | Sy-5609 | SY5609 | SY-5609)
Affinity DataKd:  0.0700nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 0.623nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 0.623nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.623nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 0.623nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377170(CHEMBL256570 | US11254667, Compound I-2 | US115422...)
Affinity DataIC50: 0.996nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50377170(CHEMBL256570 | US11254667, Compound I-2 | US115422...)
Affinity DataIC50: 0.996nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.996nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK7/cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669853(US20240132489, Compound 27 | (S)-4-(6-(3,6-dihydro...)
Affinity DataIC50: 2.17nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669874(US20240132489, Compound Mixture 105 and 106)
Affinity DataIC50: 2.70nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669878(US20240132489, Compound 110 | formate )
Affinity DataIC50: 3.48nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669855(US20240132489, Compound 29 | US20240132489, Compou...)
Affinity DataIC50: 4.36nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669880(US20240132489, Compound 113 | Monomer )
Affinity DataIC50: 4.76nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669877(US20240132489, Compound 109 | (S)-4-(6-(3,4-dihydr...)
Affinity DataIC50: 5.62nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669879(US20240132489, Compound 112 | Monomer )
Affinity DataIC50: 5.82nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669873(US20240132489, Compound 104 | formate )
Affinity DataIC50: 5.85nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669855(US20240132489, Compound 29 | US20240132489, Compou...)
Affinity DataIC50: 6.40nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669851(US20240132489, Compound 25 | (S)-4-(3-(2-(piperidi...)
Affinity DataIC50: 6.5nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669881(US20240132489, Compound 114 | formate )
Affinity DataIC50: 6.73nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669854(US20240132489, Compound 28 | formate )
Affinity DataIC50: 6.96nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669839(US20240132489, Compound 13 | 4-(6-((1S,4S)-2-oxa-5...)
Affinity DataIC50: 7.05nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669848(US20240132489, Compound 22 | (S)-4-(6-(1,4-oxazepa...)
Affinity DataIC50: 7.05nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669855(US20240132489, Compound 29 | US20240132489, Compou...)
Affinity DataIC50: 7.08nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669840(US20240132489, Compound 14 | (S)-4-(6-(2-oxa-6-aza...)
Affinity DataIC50: 7.11nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669872(US20240132489, Compound 103 | formate )
Affinity DataIC50: 7.26nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669857(US20240132489, Compound 31 | formate )
Affinity DataIC50: 8.13nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669846(US20240132489, Compound 20 | (S)-1-(3-(2-(piperidi...)
Affinity DataIC50: 8.43nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669870(US20240132489, Compound 75 | formate )
Affinity DataIC50: 8.5nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669863(US20240132489, Compound 60 | (S)—N-(6,6-dimet...)
Affinity DataIC50: 8.79nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669847(US20240132489, Compound 21 | (S)-3-methyl-1-(3-(2-...)
Affinity DataIC50: 8.81nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669844(US20240132489, Compound 18 | 4-(6-((S)-3-methylmor...)
Affinity DataIC50: 9.47nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669852(US20240132489, Compound 26 | N—((S)-6,6-dimet...)
Affinity DataIC50: 9.5nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM669882(US20240132489, Compound 115 | 4-(6-((S)-3-methylmo...)
Affinity DataIC50: 9.52nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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