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Report error Found 1342 Enz. Inhib. hit(s) with Target = 'Cyclic GMP-AMP synthase'
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250109(CHEMBL4062994)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250107(CHEMBL4085628)
Affinity DataKd:  7.80E+4nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250111(CHEMBL4084664)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250110(CHEMBL4065757)
Affinity DataKd:  1.71E+5nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250106(CHEMBL4103560)
Affinity DataKd:  1.25E+4nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human Cyclic GMP-AMP synthase (2 to 522 residues) expressed in Sf9 cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250110(CHEMBL4065757)
Affinity DataKd:  1.70E+5nMAssay Description:Binding affinity to human Cyclic GMP-AMP synthase (2 to 522 residues) expressed in Sf9 cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human cGAS assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50590391(CHEMBL5203753)
Affinity DataKd:  200nMAssay Description:Binding affinity to cGAS (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700823(US20240342186, Example 2.04)
Affinity DataIC50: 1nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685849(US12043625, Example 1.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685857(US12043625, Example 1.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685874(US12043625, Example 2.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685878(US12043625, Example 2.07)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685882(US12043625, Example 2.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685892(US12043625, Example 3.01)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685893(US12043625, Example 3.02)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700793(US20240342186, Example 1.09)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700795(US20240342186, Example 1.11)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700804(US20240342186, Example 1.20)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700824(US20240342186, Example 2.05)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688363(US20240189315, Example 11)
Affinity DataIC50: 2.80nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685848(US12043625, Example 1.02)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685863(US12043625, Example 1.17)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685866(US12043625, Example 1.20)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685872(US12043625, Example 2.01)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685881(US12043625, Example 2.10)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688391(US20240189315, Example 37)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688392(US20240189315, Example 38)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480))
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480))
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700798(US20240342186, Example 1.14)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700800(US20240342186, Example 1.16)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700812(US20240342186, Example 1.28)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700814(US20240342186, Example 1.30)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700815(US20240342186, Example 1.31)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCyclic GMP-AMP synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM700817(US20240342186, Example 1.33)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

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