Compile Data Set for Download or QSAR
Report error Found 146 Enz. Inhib. hit(s) with Target = 'Cholesterol 24-hydroxylase'
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM2483(Sustiva | DMP-266 | (4S)-6-chloro-4-(2-cyclopropyl...)
Affinity DataKd:  800nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50097571((S)-6-Chloro-4-cyclopropylethynyl-8-hydroxy-4-trif...)
Affinity DataKd:  4.10E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50097575(6-Chloro-4-cyclopropylethynyl-7-hydroxy-4-trifluor...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540104(CHEMBL4636944)
Affinity DataKd:  3.20E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540105(CHEMBL4648558)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540106(CHEMBL3344478)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540107(CHEMBL4639106)
Affinity DataKd:  2.58E+4nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540108(CHEMBL4632958)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540109(CHEMBL3344474)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540110(CHEMBL4645070)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM2483(Sustiva | DMP-266 | (4S)-6-chloro-4-(2-cyclopropyl...)
Affinity DataKd:  1.02E+4nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50097571((S)-6-Chloro-4-cyclopropylethynyl-8-hydroxy-4-trif...)
Affinity DataKd:  1.05E+4nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50097575(6-Chloro-4-cyclopropylethynyl-7-hydroxy-4-trifluor...)
Affinity DataKd:  1.01E+4nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540105(CHEMBL4648558)
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540108(CHEMBL4632958)
Affinity DataKd:  1.41E+4nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540109(CHEMBL3344474)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540110(CHEMBL4645070)
Affinity DataKd:  1.59E+4nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM2483(Sustiva | DMP-266 | (4S)-6-chloro-4-(2-cyclopropyl...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50540105(CHEMBL4648558)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609199(CHEMBL5279173)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609193(CHEMBL5288661)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609182(CHEMBL5276973)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609197(CHEMBL5282804)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609191(CHEMBL5271033)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609194(CHEMBL5269674)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393292(US9963443, Reference Example 21)
Affinity DataIC50: 4.90nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609189(CHEMBL5289771)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393278(US9963443, Reference Example 1)
Affinity DataIC50: 5.40nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609195(CHEMBL5284673)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393291(US9963443, Reference Example 20)
Affinity DataIC50: 6.90nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393282(US9963443, Reference Example 4)
Affinity DataIC50: 7.10nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583509(CHEMBL5093928)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393280(US9963443, Reference Example 3)
Affinity DataIC50: 7.40nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583519(SOTICLESTAT | Soticlestat | OV-935 | OV935 | TAK-9...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583519(SOTICLESTAT | Soticlestat | OV-935 | OV935 | TAK-9...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609192(CHEMBL5275089)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609196(CHEMBL5275183)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583501(CHEMBL4594072)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583512(CHEMBL4532699)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393279(US9963443, Reference Example 2)
Affinity DataIC50: 8.80nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583515(CHEMBL4527933)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393297(US9963443, Reference Example 26)
Affinity DataIC50: 10nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583517(CHEMBL4538165)
Affinity DataIC50: 12nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583518(CHEMBL5083867)
Affinity DataIC50: 12nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583508(CHEMBL5076011)
Affinity DataIC50: 14nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393285(US9963443, Reference Example 11)
Affinity DataIC50: 16nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50583507(CHEMBL5082831)
Affinity DataIC50: 16nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50609181(CHEMBL5286208)
Affinity DataIC50: 16nMAssay Description:Inhibition of full length N-terminal his6-tagged human CH24H (28 to 494 residues) expressed in Escherichia coli DH5alpha using [14C] cholesterol as s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393288(US9963443, Reference Example 14)
Affinity DataIC50: 17nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCholesterol 24-hydroxylase(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM393296(US9963443, Reference Example 23)
Affinity DataIC50: 17nMAssay Description:For the measurement of CH24H inhibitory activity, using the human CH24H lysate prepared in Experimental Example 2, the amount of 24-HC produced from ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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