Compile Data Set for Download or QSAR
Report error Found 666 Enz. Inhib. hit(s) with Target = 'Ceramide glucosyltransferase'
TargetCeramide glucosyltransferase(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50406130(CHEMBL5272946)
Affinity DataEC50:  320nMAssay Description:Invivo inhibition of GCS in C57 mouse assessed as reduction in brain GlcCer d18:1/18:0 concentration measured after 8 hrs by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576415(WO2022115301, Example 1 | (R)-2-(1-Cyclopropyl-2-h...)
Affinity DataEC50:  7.90nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576416(WO2022115301, Example 2 | (R or S)-2-(1-Cyclopropy...)
Affinity DataEC50:  2.60nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576417(WO2022115301, Example 3 | (R)-2-(1-Cyclopropyl-2-h...)
Affinity DataEC50:  2nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576418(WO2022115301, Example 4 | (R and S)- (E)-2-(1-cycl...)
Affinity DataEC50:  290nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576419(WO2022115301, Example 5)
Affinity DataEC50:  52nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576420(WO2022115301, Example 6)
Affinity DataEC50:  4.5nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576421(WO2022115301, Example 7)
Affinity DataEC50:  3.60nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576422(WO2022115301, Example 8)
Affinity DataEC50:  7.5nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576423(WO2022115301, Example 9)
Affinity DataEC50:  24nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576424(WO2022115301, Example 10)
Affinity DataEC50:  2.80nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576425(WO2022115301, Example 11)
Affinity DataEC50:  4.90nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576426(WO2022115301, Example 12)
Affinity DataEC50:  13nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576427(WO2022115301, Example 13)
Affinity DataEC50:  260nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576428(WO2022115301, Example 14)
Affinity DataEC50:  48nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576429(WO2022115301, Example 15)
Affinity DataEC50:  6.40nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576430(WO2022115301, Example 16)
Affinity DataEC50:  39nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576431(WO2022115301, Example 17)
Affinity DataEC50:  580nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576432(WO2022115301, Example 18)
Affinity DataEC50:  45nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576433(WO2022115301, Example 19)
Affinity DataEC50:  28nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576434(WO2022115301, Example 20)
Affinity DataEC50:  67nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576435(WO2022115301, Example 21)
Affinity DataEC50:  0.910nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576436(WO2022115301, Example 22)
Affinity DataEC50:  6.90nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576437(WO2022115301, Example 23)
Affinity DataEC50:  0.410nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576438(WO2022115301, Example 24)
Affinity DataEC50:  0.930nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576439(WO2022115301, Example 25)
Affinity DataEC50:  9.20nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50597260(CHEMBL5182897 | US20230391758, Compound 20)
Affinity DataEC50:  0.0200nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50597261(CHEMBL5170109 | US20230391758, Compound 21)
Affinity DataEC50:  0.0210nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50597262(CHEMBL5191157 | US20230391758, Compound 22)
Affinity DataEC50:  0.0230nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50597263(CHEMBL5177098 | US20230391758, Compound 23)
Affinity DataEC50:  0.0440nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50597264(CHEMBL5195638 | US20230391758, Compound 24)
Affinity DataEC50:  0.0440nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50597265(CHEMBL5197108)
Affinity DataEC50:  0.0470nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639299(5-fluoro-N-(trans-4-(hydroxymethyl)cyclohexyl)-7-(...)
Affinity DataEC50:  0.990nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639300(N-(1,6-naphthyridin-2-yl)-7- (1,3,5-trimethylpyraz...)
Affinity DataEC50:  0.0650nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639301(7-(5-cyano-2-methoxy-phenyl)- N-(4-hydroxynorborna...)
Affinity DataEC50:  0.0970nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639302(7-[5-cyano-2- (difluoromethoxy)phenyl]-N- (4-hydro...)
Affinity DataEC50:  0.100nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639303(5-chloro-7-(5-cyano-2- methoxy-phenyl)-N-[(1R,3S)-...)
Affinity DataEC50:  0.170nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639304(7-[5-chloro-2- (difluoromethoxy)-3-pyridyl]- N-(4-...)
Affinity DataEC50:  0.870nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639305(N-(3-pyridyl)-7-[2-(2,2,2- trifluoroethoxy)phenyl]...)
Affinity DataEC50:  0.990nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639306(7-(5-chloro-2-methoxy-3- pyridyl)-N-(4- hydroxynor...)
Affinity DataEC50:  1.10nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639307((R and S)-N-[3-(2-hydroxy-1- methyl-ethyl)-1- bicy...)
Affinity DataEC50:  1.70nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639308(7-(2-propoxyphenyl)-N-(3- pyridyl)benzofuran-2- ca...)
Affinity DataEC50:  1.80nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639309(N-(2-fluoro-4-hydroxy- cyclohexyl)-7-[2-(2,2,2- tr...)
Affinity DataEC50:  7.10nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639310(N-(6-methyl-2-pyridyl)-7- (1,3,5-trimethylpyrazol-...)
Affinity DataEC50:  21nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639311(7-(2-butoxyphenyl)-N-(2- hydroxy-1,1-dimethyl- eth...)
Affinity DataEC50:  28nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639312((R and S)-N-(4,4-difluoro-3- piperidyl)-7-[2-(2,2,...)
Affinity DataEC50:  0.480nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639313(N-(trans-4-fluoro-3-piperidyl)- 7-[2-(2,2,2- trifl...)
Affinity DataEC50:  1.70nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639314(N-[(3S,4S)-3-fluoro-4- piperidyl]-7-[2- (trifluoro...)
Affinity DataEC50:  2.70nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639315(5-fluoro-N-[4- (hydroxymethyl)-1- bicyclo[2.2.2]oc...)
Affinity DataEC50:  0.890nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM639316(N-[(4R or 4S)-3,3-difluoro-4- piperidyl]-7-(2- pro...)
Affinity DataEC50:  140nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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