Compile Data Set for Download or QSAR
Report error Found 3804 Enz. Inhib. hit(s) with Target = 'Cathepsin S'
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121541(Morpholine-4-carboxylic acid (1-{[cyano-(2-methyl-...)
Affinity DataKd:  3nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121543(Morpholine-4-carboxylic acid {1-[(cyano-phenyl-met...)
Affinity DataKd:  1nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121546(Morpholine-4-carboxylic acid {1-[(cyano-phenyl-met...)
Affinity DataKd:  4nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121548(MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-C...)
Affinity DataKd:  0.300nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121551(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKd:  9nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121552(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKd:  60nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121553(Morpholine-4-carboxylic acid [1-(1-cyanomethyl-3-p...)
Affinity DataKd: >2.00E+4nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121554(N-{1-[(Benzyloxymethyl-cyano-methyl)-carbamoyl]-2-...)
Affinity DataKd:  0.700nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121547(Morpholine-4-carboxylic acid {1-[(benzyl-cyano-met...)
Affinity DataKd:  63nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121558(Morpholine-4-carboxylic acid (1-{[cyano-(2-methyl-...)
Affinity DataKd:  0.300nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121560(Morpholine-4-carboxylic acid [(1-cyano-3-phenyl-pr...)
Affinity DataKd:  5nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121561(Morpholine-4-carboxylic acid (1-{[(3-chloro-benzyl...)
Affinity DataKd:  0.5nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121562(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKd:  0.800nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121564(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKd:  7nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121566(Morpholine-4-carboxylic acid (1-{[cyano-(3,4-dichl...)
Affinity DataKd:  7nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121570(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKd:  0.900nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121569(Morpholine-4-carboxylic acid {1-[(benzyloxymethyl-...)
Affinity DataKd:  0.600nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121572(Morpholine-4-carboxylic acid {1-[(cyano-dimethyl-m...)
Affinity DataKd:  4nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121545(Morpholine-4-carboxylic acid (1-{[(2-chloro-benzyl...)
Affinity DataKd:  0.300nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121542(Thiophene-2-carboxylic acid {1-[(benzyloxymethyl-c...)
Affinity DataKd:  0.100nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121575(Morpholine-4-carboxylic acid (1-{[cyano-(2-methyl-...)
Affinity DataKd:  0.100nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121576(Furan-2-carboxylic acid {1-[(benzyloxymethyl-cyano...)
Affinity DataKd:  0.400nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121573(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKd:  28nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121557(Morpholine-4-carboxylic acid (1-{[(4-chloro-benzyl...)
Affinity DataKd:  2nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121549(N-((S)-1-((R)-2-(benzyloxy)-1-cyanoethylamino)-3-c...)
Affinity DataKd:  0.400nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121581(Morpholine-4-carboxylic acid (1-{[(2-chloro-benzyl...)
Affinity DataKd:  0.400nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121544(Pyrazine-2-carboxylic acid {1-[(benzyloxymethyl-cy...)
Affinity DataKd:  0.600nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208836((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-4-...)
Affinity DataKd:  5.40nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208839((R)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-2-(cyclohex...)
Affinity DataKd:  4.39nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208840((R)-N-((R)-3-cyano-1-isopropylpyrrolidin-3-yl)-2-(...)
Affinity DataKd:  60.6nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208838((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-2-...)
Affinity DataKd:  23.1nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208837((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-2-...)
Affinity DataKd:  13.8nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208845((R)-N-(1-benzyl-4-cyanopiperidin-4-yl)-2-(cyclohex...)
Affinity DataKd:  52nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208847((R)-N-(1-cyanocyclopropyl)-2-(cyclohexylmethyl)-4-...)
Affinity DataKd:  12nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208846((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-2-...)
Affinity DataKd:  17.8nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208849((R)-N-((R)-3-cyano-1-isobutylpyrrolidin-3-yl)-2-(c...)
Affinity DataKd:  53.3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208848((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-2-...)
Affinity DataKd:  77.3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208852((R)-N-((S)-1-benzyl-3-cyanopyrrolidin-3-yl)-2-(cyc...)
Affinity DataKd:  3.64nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208853((R)-N-((S)-3-cyano-1-(cyclohexylmethyl)pyrrolidin-...)
Affinity DataKd:  13.8nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208842((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-2-...)
Affinity DataKd:  59nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208843((R)-N-((S)-1-cyano-3-phenylpropyl)-2-(cyclohexylme...)
Affinity DataKd:  25nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208855((R)-N-((R)-3-cyano-1-(cyclopropylmethyl)pyrrolidin...)
Affinity DataKd:  20nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208851((R)-N-(4-cyano-1-methylpiperidin-4-yl)-2-(cyclohex...)
Affinity DataKd:  177nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208856((R)-N-((R)-3-cyano-1-phenethylpyrrolidin-3-yl)-2-(...)
Affinity DataKd:  15.2nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208850((R)-N-((R)-3-cyano-1-methylpyrrolidin-3-yl)-2-(cyc...)
Affinity DataKd:  161nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208844((R)-N-((R)-2-(3-chlorobenzyloxy)-1-cyanoethyl)-2-(...)
Affinity DataKd:  4.86nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208858((R)-N-((R)-3-cyano-1-cycloheptylpyrrolidin-3-yl)-2...)
Affinity DataKd:  11nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208854((R)-N-((R)-3-cyanopyrrolidin-3-yl)-2-(cyclohexylme...)
Affinity DataKd:  123nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50322923(6-(4-(3-(4-methylpiperazin-1-yl)propoxy)-3-(triflu...)
Affinity DataEC50:  138nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as induction of accumulation of lip10More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546793(CHEMBL4792093)
Affinity DataKd:  9.60E+4nMAssay Description:Binding affinity to 15N-labeled His6-tagged Cathepsin S (unknown origin) expressed in Escherichia coli by 2D 15N-HSQC-NMR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
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