Compile Data Set for Download or QSAR
Report error Found 257 Enz. Inhib. hit(s) with Target = 'Catechol O-methyltransferase'
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019330(CHEMBL3289429)
Affinity DataKd:  2.51E+5nMAssay Description:Binding affinity to NHS-PEG4-Biotin-labeled human COMT after 1 hr by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019331(CHEMBL3289430)
Affinity DataKd:  3.16E+4nMAssay Description:Binding affinity to NHS-PEG4-Biotin-labeled human COMT after 1 hr by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019332(CHEMBL3289431)
Affinity DataKd:  6.31E+4nMAssay Description:Binding affinity to NHS-PEG4-Biotin-labeled human COMT after 1 hr by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019333(CHEMBL3289432)
Affinity DataKd:  2.51E+4nMAssay Description:Binding affinity to NHS-PEG4-Biotin-labeled human COMT after 1 hr by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534432(CHEMBL4463709)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 0.912nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50450447(CHEMBL4171117)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-terminal hexa-His tagged rat MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50450450(CHEMBL4172614)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-terminal hexa-His tagged rat MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50450452(CHEMBL4167128)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-terminal hexa-His tagged rat MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50450448(CHEMBL4176008)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-terminal hexa-His tagged rat MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534437(CHEMBL4437043)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534438(CHEMBL4447349)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534438(CHEMBL4447349)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Catechol O-methyltransferase activity in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of rat COMTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017865(CHEMBL265218 | 2,5-Bis-(3,4-dihydroxy-5-nitro-benz...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534433(CHEMBL4448310)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50: 3.47nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108878(CHEMBL160038 | 1-(3,4-Dihydroxy-5-nitro-phenyl)-2-...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of Catechol O-methyltransferase activity in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534435(CHEMBL4543735)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534435(CHEMBL4543735)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534434(CHEMBL4444830)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534434(CHEMBL4444830)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50479610(CHEMBL481644)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017845(CHEMBL168600 | 3-(3,4-Dihydroxy-5-nitro-phenyl)-1-...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50479610(CHEMBL481644)
Affinity DataIC50: 5nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534436(CHEMBL4437795)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50479631(CHEMBL137555)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017857(CHEMBL169926 | 3-(3,4-Dihydroxy-5-nitro-phenyl)-1-...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM84475(Bi-substrate Inhibitor, 1a)
Affinity DataIC50: 9nMT: 2°CAssay Description:The binding affinity of the inhibitors towards Catechol O-methyltransferase in the presence of Mg2+ ions were determined by using a radiochemical ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50167083(CHEMBL3800482)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant rat C-terminal His10-tagged MB-COMT transfected in Escherichia coli BL21-CodonPlus(DE3)-RIPL using SAM/dopamine as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534437(CHEMBL4437043)
Affinity DataIC50: 11nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017846(CHEMBL168276 | 3,5-DINITROCATECHOL | 3,5-Dinitro-b...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017852(CHEMBL167054 | 4-(3,4-Dihydroxy-5-nitro-phenyl)-3-...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017846(CHEMBL168276 | 3,5-DINITROCATECHOL | 3,5-Dinitro-b...)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat brain COMT using pyrocatechol as substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50: 12.8nMAssay Description:Inhibition of Catechol O-methyltransferase activity in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50534432(CHEMBL4463709)
Affinity DataIC50: 13nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50479631(CHEMBL137555)
Affinity DataIC50: 13nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50167074(CHEMBL3799913)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant rat C-terminal His10-tagged MB-COMT transfected in Escherichia coli BL21-CodonPlus(DE3)-RIPL using SAM/dopamine as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50167086(CHEMBL3798212)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant rat C-terminal His10-tagged MB-COMT transfected in Escherichia coli BL21-CodonPlus(DE3)-RIPL using SAM/dopamine as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017844(CHEMBL169033 | 1-(3,4-Dihydroxy-5-nitro-phenyl)-et...)
Affinity DataIC50: 16nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50086213(CHEMBL3425734)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017848(CHEMBL167055 | 3-(3,4-Dihydroxy-5-nitro-benzyliden...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017861(CHEMBL168389 | 2-Cyano-3-(3,4-dihydroxy-5-nitro-ph...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50017866(CHEMBL350927 | N-Adamantan-1-yl-3,4-dihydroxy-5-ni...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibitory activity against catechol O-methyltransferase of rat brain using 3,4-dihydroxybenzoic acid as the substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50086210(CHEMBL3425739)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Displayed 1 to 50 (of 257 total ) | Next | Last >>
Jump to: