Compile Data Set for Download or QSAR
Report error Found 462 Enz. Inhib. hit(s) with Target = 'Caspase-8'
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM10323(JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-be...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273339((S)-1-(4-Fluorobenzyl)-5-(2-((1-(2-fluoroethyl)-1H...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273338((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273992((S)-1-(2-Propynyl)-5-(2-(2,4-difluorophenoxymethyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273991((S)-1-(4-Fluorobenzyl)-5-(2-(pyrimidin-4-yloxymeth...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273990((S)-1-(4-Fluorobenzyl)-5-(2-(tetrahydro-2H-pyran-4...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273989((S)-1-(4-Fluorobenzyl)-5-(2-(3,5-difluorophenoxyme...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273929((S)-1-(4-Fluorobenzyl)-5-(2-(2,4-difluorophenoxyme...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273928((S)-1-(4-Fluorobenzyl)-5-(2-(3-fluorophenoxymethyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273927((S)-1-(4-Fluorobenzyl)-5-(2-(4-fluorophenoxymethyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273926(1-(4-Fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isati...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM10331((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolid...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50200305((S)-1-(4-iodobenzyl)-5-(2-phenoxymethyl-pyrrolidin...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 8 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM10652((3S)-3-[(2S)-2-[(4S)-4-[(3S)-3-acetamido-3-formami...)
Affinity DataIC50: 0.0160nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160960((S)-3-{(S)-2-[3-((S)-2-Acetylamino-3-carboxy-propi...)
Affinity DataIC50: 0.220nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160961((S)-5-Benzylsulfanyl-3-{(S)-2-[2-(5-methanesulfony...)
Affinity DataIC50: 0.490nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160965((S)-3-(2-{3-[(4-Methyl-furazan-3-ylmethyl)-amino]-...)
Affinity DataIC50: 0.990nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM572147(US11447497, Example 4)
Affinity DataIC50: 1nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160953((S)-5-Benzylsulfanyl-3-(2-{3-[2-(3,5-dimethyl-pyra...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160948((S)-5-Benzylsulfanyl-4-oxo-3-(2-{2-oxo-3-[(thiazol...)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160949((S)-5-Benzylsulfanyl-4-oxo-3-(2-{2-oxo-3-[(thiophe...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160974([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160990((S)-5-Benzylsulfanyl-4-oxo-3-{2-[2-oxo-3-(2-pyrazo...)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160947((S)-5-Benzylsulfanyl-3-(2-{3-[(4-methyl-furazan-3-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160986((S)-5-Benzylsulfanyl-3-{2-[3-(2-methyl-benzothiazo...)
Affinity DataIC50: 2.70nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160975((S)-5-Benzylsulfanyl-3-(2-{3-[(isoxazol-3-ylmethyl...)
Affinity DataIC50: 2.90nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160972((S)-5-Benzylsulfanyl-3-(2-{3-[(3-methyl-isoxazol-5...)
Affinity DataIC50: 3.30nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160957([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50175337((4S,7S,11aS)-benzyl 4-(((3S)-2-hydroxy-5-oxo-tetra...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against Caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM10357((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 4.20nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50340547((4S,7S,10S,13S)-4-sec-butyl-7-(2-carboxyethyl)-13-...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of caspase 8 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160977((S)-5-[(1,3-Dihydro-isoindol-2-ylmethyl)-amino]-3-...)
Affinity DataIC50: 4.30nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM10357((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 4.70nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160980((S)-5-Benzylsulfanyl-4-oxo-3-(2-{2-oxo-3-[(5-pheny...)
Affinity DataIC50: 4.90nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50175323((4S,7S,11aS)-benzyl 4-(((3S)-2-hydroxy-5-oxo-tetra...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against Caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50: 5.30nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50153668(3-[(S)-2-(2,4-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50: 6nMAssay Description:Inhibition concentration required against caspase-8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160951((S)-5-[(4-Benzyl-piperidin-1-ylmethyl)-amino]-3-(2...)
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160987((S)-3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylme...)
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160956((S)-3-(2-{3-[(4-Methyl-furazan-3-ylmethyl)-amino]-...)
Affinity DataIC50: 6.20nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160945((S)-5-Benzylsulfanyl-3-(2-{3-[(3-methyl-[1,2,4]oxa...)
Affinity DataIC50: 6.40nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160989((S)-3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylme...)
Affinity DataIC50: 6.5nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160973((S)-5-Benzylsulfanyl-4-oxo-3-(2-{2-oxo-3-[(thiazol...)
Affinity DataIC50: 6.60nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50: 7nMAssay Description:Binding affinity towards human Caspase-8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 7nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160954((S)-5-[(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-ami...)
Affinity DataIC50: 7.40nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50119262(4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50160963((S)-5-Benzylsulfanyl-3-(2-{3-[(5-methyl-[1,2,4]oxa...)
Affinity DataIC50: 7.60nMAssay Description:Inhibitory concentration against recombinant human caspase-8 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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