Compile Data Set for Download or QSAR
Report error Found 949 Enz. Inhib. hit(s) with Target = 'Breakpoint cluster region protein'
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataEC50:  0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataEC50:  0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataEC50:  0.0500nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataEC50:  34nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataEC50:  1.80nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328120(1-benzyl-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazol...)
Affinity DataEC50:  400nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328121(1-(pyridin-3-ylmethyl)-N-(4-(trifluoromethoxy)phen...)
Affinity DataEC50:  7.15E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328122(4-((4-(4-(trifluoromethoxy)phenylamino)-1H-pyrazol...)
Affinity DataEC50:  6.89E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328123(1-((tetrahydrofuran-3-yl)methyl)-N-(4-(trifluorome...)
Affinity DataEC50:  690nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328124(1-tert-butyl-N-(4-(trifluoromethoxy)phenyl)-1H-pyr...)
Affinity DataEC50:  160nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328125(1-(pyridin-4-ylmethyl)-N-(4-(trifluoromethoxy)phen...)
Affinity DataEC50:  2.96E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328126(1-((2,4-dimethylthiazol-5-yl)methyl)-N-(4-(trifluo...)
Affinity DataEC50:  6.92E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328127(N-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]p...)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328128(2-(4-(4-(Trifluoromethoxy)phenylamino)-2H-pyrazolo...)
Affinity DataEC50:  1.32E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328129(2-ethyl-N-(4-(trifluoromethoxy)phenyl)-2H-pyrazolo...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328130(2-propyl-N-(4-(trifluoromethoxy)phenyl)-2H-pyrazol...)
Affinity DataEC50:  160nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328131(2-cyclohexyl-N-(4-(trifluoromethoxy)phenyl)-2H-pyr...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328132(2-(4-(4-(trifluoromethoxy)phenylamino)-2H-pyrazolo...)
Affinity DataEC50:  4.34E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328133(2-benzyl-N-(4-(trifluoromethoxy)phenyl)-2H-pyrazol...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328134(2-(pyridin-3-ylmethyl)-N-(4-(trifluoromethoxy)phen...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataKd:  92nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328135(N-(4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin...)
Affinity DataKd:  114nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328136(6-(1H-pyrazol-4-yl)-N-(4-(trifluoromethoxy)phenyl)...)
Affinity DataKd:  43nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328137(6-(1-methyl-1H-pyrazol-4-yl)-N-(4-(trifluoromethox...)
Affinity DataKd:  57nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328138((4-methylpiperazin-1-yl)(4-(4-(trifluoromethoxy)ph...)
Affinity DataKd:  46nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328122(4-((4-(4-(trifluoromethoxy)phenylamino)-1H-pyrazol...)
Affinity DataKd:  598nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328125(1-(pyridin-4-ylmethyl)-N-(4-(trifluoromethoxy)phen...)
Affinity DataKd:  394nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328126(1-((2,4-dimethylthiazol-5-yl)methyl)-N-(4-(trifluo...)
Affinity DataKd:  526nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328139(N4-(2-morpholinoethyl)-N6-(4-(trifluoromethoxy)phe...)
Affinity DataEC50:  720nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328140(N4-(3-morpholinopropyl)-N6-(4-(trifluoromethoxy)ph...)
Affinity DataEC50:  4.47E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328141(6-morpholino-N-(4-(trifluoromethoxy)phenyl)pyrimid...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328142(6-(1H-imidazol-1-yl)-N-(4-(trifluoromethoxy)phenyl...)
Affinity DataEC50:  1.66E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328143(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328144(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50:  2.92E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50:  140nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328145(4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50:  480nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328146(2-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328147(6-(pyridin-4-yl)-N-(4-(trifluoromethoxy)phenyl)pyr...)
Affinity DataEC50:  470nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328148(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50:  580nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328149(6-(3-(methylsulfonyl)phenyl)-N-(4-(trifluoromethox...)
Affinity DataEC50:  390nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328150(6-(3-aminophenyl)-N-(4-(trifluoromethoxy)phenyl)py...)
Affinity DataEC50:  330nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328151(4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataEC50:  120nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328135(N-(4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin...)
Affinity DataEC50:  40nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328152(N-(2-hydroxyethyl)-3-(6-(4-(trifluoromethoxy)pheny...)
Affinity DataEC50:  430nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328153(N-(2-morpholinoethyl)-3-(6-(4-(trifluoromethoxy)ph...)
Affinity DataEC50:  420nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50328154(N-methyl-3-(6-(4-(trifluoromethoxy)phenylamino)pyr...)
Affinity DataEC50:  340nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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