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Report error Found 15 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1/2'
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  2.70E+4nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataEC50:  23nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(CHEMBL190346 | cid_11198061 | 1-(3-Acetyl-phenyl)-...)
Affinity DataEC50:  11nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  3.5nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186049(US9163011, 3)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186080(US9163011, 35)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186055(US9163011, 9)
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186075(US9163011, 30)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186053(US9163011, 7)
Affinity DataIC50: 27nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50100436(CHEMBL412768 | NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of beta-secretase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186050(US9163011, 4)
Affinity DataIC50: 49nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 300nMAssay Description:Inhibition of beta-secretase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM186057(US9163011, 11)
Affinity DataIC50: 440nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50470133(CHEMBL277046)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against aspartyl proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed