Compile Data Set for Download or QSAR
Report error Found 4358 Enz. Inhib. hit(s) with Target = 'Beta-lactamase'
TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM427412(US10544130, Example 248 | (3R)-3-{[4-(2-amino-1H-1...)
Affinity DataIC50: 0.0350nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361172(4-(2-Amino-7-methyl-1H-benzo[d]imidazol-4-yl)-N1-(...)
Affinity DataIC50: 0.0430nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361236((R)—N1-(1-aminopropan-2-yl)-4-(6-aminopyridin...)
Affinity DataIC50: 0.0450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361042(US10221163, Example 199 | N1-(2-aminoethyl)-4-(1H-...)
Affinity DataIC50: 0.0470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50274047(CHEMBL3613796)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of Escherichia coli AmpC using CENTA as substrate by spectrometry based Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367839(US10227331, Example 26 | (2-amino-3- cyanophenyl) ...)
Affinity DataIC50: 0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase 1(Bacillus cereus)
Universidade De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50450973(CHEMBL4209255)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of Bacillus cereus beta-lactamase AmpC using CENTA as substrate up to 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530895(US11207312, Example 27 | (R)-4-(4-(2-(1H-pyrazol- ...)
Affinity DataIC50: 0.0500nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361341((R)-N1-(4-aminobutan-2- yl)-4-(6-aminopyridin-3- y...)
Affinity DataIC50: 0.0510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361124((R)-4-(2-methyl-2H- benzo[d][1,2,3]triazol-4- yl)-...)
Affinity DataIC50: 0.0520nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361144((R)-4-(1H- benzo[d]imidazol-4-yl)- N1-(3-amino-2- ...)
Affinity DataIC50: 0.0530nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361227((R)—N1-(1-aminopropan-2-yl)-4-(imidazo[1,2-a]...)
Affinity DataIC50: 0.0540nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361080(US10221163, Example 237 | US10544130, Example 237)
Affinity DataIC50: 0.0550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361149((S)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminom...)
Affinity DataIC50: 0.0560nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361068((R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-...)
Affinity DataIC50: 0.0560nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361091((3R)-3-{[4-(2-amino-1H-1,3-benzodiazol-4-yl)-2-sul...)
Affinity DataIC50: 0.0610nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360985(US10221163, Example 141 | 4'-((4R,5S)-4-methyl-2- ...)
Affinity DataIC50: 0.0620nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361081(US10221163, Example 238 | US10544130, Example 238)
Affinity DataIC50: 0.0650nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361143((R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminom...)
Affinity DataIC50: 0.0680nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361134((R)-4-(imidazo[1,2- a]pyridin-8-yl)-N1- (pyrrolidi...)
Affinity DataIC50: 0.0690nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM427664((R)—N1-(1-(2-aminoethyl)pyrrolidin-3-yl)-4-(6...)
Affinity DataIC50: 0.0710nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361314(US10221163, Example 471 | (R)-2-((4′-(N-(pyr...)
Affinity DataIC50: 0.0730nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360930(US10221163, Example 86 | 4-(2- aminobenzo [d]thiaz...)
Affinity DataIC50: 0.0760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361131((R)-4-(2-aminopyridin- 4-yl)-N1-(pyrrolidin-3- yl)...)
Affinity DataIC50: 0.0780nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361077((R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1...)
Affinity DataIC50: 0.0830nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361085(US10221163, Example 242 | US10544130, Example 242)
Affinity DataIC50: 0.0840nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361318((S)-N1-(1-amino-3- hydroxypropan-2-yl)-4-(2- (amin...)
Affinity DataIC50: 0.0870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361312((S)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50: 0.0870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361311((S)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- me...)
Affinity DataIC50: 0.0870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361129((R)-4-(2-aminoquinolin- 8-yl)-N1-(pyrrolidin-3- yl...)
Affinity DataIC50: 0.0880nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361119((R)-4-(2-(aminomethyl)benzo[d]thiazol-4-yl)-N1-(py...)
Affinity DataIC50: 0.0880nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361025(US10221163, Example 182 | 4-(2-amino-1H-benzo[d]im...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361244(US10221163, Example 401 | US10544130, Example 401)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361118((R)-4-(2-(aminomethyl)benzo[d]thiazol-5-yl)-N1-(py...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361076((R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sul...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360850(US10221163, Example 6 | 4-(2-amino-7- methylbenzo[...)
Affinity DataIC50: 0.0910nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361306((R)—N1-(3-amino-2-hydroxypropyl)-4-(2-(aminom...)
Affinity DataIC50: 0.0910nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361321((R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50: 0.0910nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361128((R)-4-(2-amino-7- methyl-1H- benzo[d]imidazol-4-yl...)
Affinity DataIC50: 0.0920nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361108((R)-4-(2-amino-1H-benzo[d] imidazol-4-yl)-N1-(1- a...)
Affinity DataIC50: 0.0930nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361204(N1-(2-aminoethyl)- 4-(imidazo[1,2- a]pyridin-8-yl)...)
Affinity DataIC50: 0.0950nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM427555(US10544130, Example 391 | 2-({[4-(2-amino-1,3- ben...)
Affinity DataIC50: 0.0970nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361030(US10221163, Example 187 | 4-(2-amino-1H-benzo[d]im...)
Affinity DataIC50: 0.0980nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361221((R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]p...)
Affinity DataIC50: 0.0980nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361210((R)-4-(2-aminobenzo[d]thiazol-4-yl)-N1-((3-aminopy...)
Affinity DataIC50: 0.0980nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361114((R)-4-(4-(N-(pyrrolidin-3-yl)sulfamoyl)-3-sulfamoy...)
Affinity DataIC50: 0.0990nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM530978(US11207312, Example 110 | 4-[4-(pyridin-2- yloxy)p...)
Affinity DataIC50: 0.100nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM427556(US10544130, Example 392 | 3-({[4-(2-amino-1,3- ben...)
Affinity DataIC50: 0.101nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361333((R)-4-(6-aminopyridin-3- yl)-N1-(piperidin-3-yl)-3...)
Affinity DataIC50: 0.101nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361117((R)-4-(2-(aminomethyl)-1H-benzo[d]imidazol-5-yl)-N...)
Affinity DataIC50: 0.102nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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