Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with Target = 'Beta-hexosaminidase subunit beta'
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50491601(CHEMBL2333316)
Affinity DataIC50: 3.10E+3nMAssay Description:Competitive inhibition of human beta-N-acetyl-D-hexosaminidase-B using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate assessed as re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM304400(US10143668, Compound 1d)
Affinity DataIC50: 3.10E+3nMAssay Description:Buffers and solutions: Phosphate buffered saline (PBS) and 1 M HEPES were provided by the in-house service facility. Tyrode's buffer (TyB) consis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM304327(US10143668, Compound 1a)
Affinity DataIC50: 3.80E+3nMAssay Description:Buffers and solutions: Phosphate buffered saline (PBS) and 1 M HEPES were provided by the in-house service facility. Tyrode's buffer (TyB) consis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50034220(n-hexadecylphosphocholine | CHEMBL125 | hexadecyl ...)
Affinity DataIC50: 4.20E+3nMAssay Description:Buffers and solutions: Phosphate buffered saline (PBS) and 1 M HEPES were provided by the in-house service facility. Tyrode's buffer (TyB) consis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 4.50E+3nMpH: 7.0Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM304339(US10143668, Compound 1b)
Affinity DataIC50: 4.90E+3nMAssay Description:Buffers and solutions: Phosphate buffered saline (PBS) and 1 M HEPES were provided by the in-house service facility. Tyrode's buffer (TyB) consis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 9.10E+3nMpH: 4.5Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM304357(US10143668, Compound 1c)
Affinity DataIC50: 1.23E+4nMAssay Description:Buffers and solutions: Phosphate buffered saline (PBS) and 1 M HEPES were provided by the in-house service facility. Tyrode's buffer (TyB) consis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 1.50E+4nMpH: 7.0Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 3.80E+4nMpH: 4.5Assay Description:Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507466(CHEMBL4564362)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using 4-Mu-GlcNAc as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM36548(N-[1-(7-{bis[(4-methoxyphenyl)methyl]amino}heptyl)...)
Affinity DataKi:  0.690nM ΔG°:  -53.2kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM36547(N-[4,5-dihydroxy-6-(hydroxymethyl)-1-(7-{[(4-metho...)
Affinity DataKi:  1.20nM ΔG°:  -51.8kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM36546(N-[1-(7-aminoheptyl)-4,5-dihydroxy-6-(hydroxymethy...)
Affinity DataKi:  2.10nM ΔG°:  -50.4kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM40762(Iminocyclitol, 4)
Affinity DataKi:  24nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM36549(N-{7-[5-acetamido-3,4-dihydroxy-2-(hydroxymethyl)p...)
Affinity DataKi:  26.7nM ΔG°:  -44.0kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM40761(Iminocyclitol, 3)
Affinity DataKi:  40nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM40760(Iminocyclitol, 2)
Affinity DataKi:  65nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513954(CHEMBL4527453)
Affinity DataKi:  70nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside as subs...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327038((3aR,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,...)
Affinity DataKi:  190nMAssay Description:Inhibition of human HexBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM40759(Iminocyclitol, 1)
Affinity DataKi:  240nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327038((3aR,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,...)
Affinity DataKi:  290nMAssay Description:Competitive inhibition of human beta-N-acetyl-D-hexosaminidase-B using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate assessed as re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50182804(CHEMBL382689 | N-[4,5-dihydroxy-6-(hydroxymethyl)p...)
Affinity DataKi:  540nM ΔG°:  -36.4kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM205423(US9243020, 17 | US9815861, Example 17)
Affinity DataKi:  790nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM40763(Iminocyclitol, 6)
Affinity DataKi:  860nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50182804(CHEMBL382689 | N-[4,5-dihydroxy-6-(hydroxymethyl)p...)
Affinity DataKi:  1.20E+3nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507470(CHEMBL4448965)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513934(CHEMBL4443587)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507475(CHEMBL4435797)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507463(CHEMBL4452208)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513958(CHEMBL4473252)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM36550(N-[1-(7-azidoheptyl)-4,5-dihydroxy-6-(hydroxymethy...)
Affinity DataKi:  1.70E+3nM ΔG°:  -33.5kJ/molepH: 4.25 T: 2°CAssay Description:Enzyme inhibition activity assay using 4-methylumbelliferyl N-acetylglucosamine (MUG) as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507469(CHEMBL4454357)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507472(CHEMBL4548064)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507462(CHEMBL4548738)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513955(CHEMBL4483089)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM205425(US9243020, 20 | US9815861, Example 20)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507476(CHEMBL4555514)
Affinity DataKi:  4.40E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM141965(US8927507, 16)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM40765(Iminocyclitol, 8)
Affinity DataKi:  5.00E+3nMAssay Description:Hexosaminidase activity assay was measured by fluorometry, VersaFluor Fluorometer from Bio-Rad.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50507471(CHEMBL4540913)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of recombinant human His6-tagged HexB expressed in Pichia pastoris using varying levels of 4-Mu-GlcNAc as substrate preincubated for 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM205422(US9243020, 9 | US9815861, Example 9)
Affinity DataKi:  8.10E+3nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513959(CHEMBL4465511)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513938(CHEMBL4552866)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513952(CHEMBL4576476)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513953(CHEMBL4449194)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513941(CHEMBL4519186)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513937(CHEMBL4520749)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50513956(CHEMBL4448352)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-hexosaminidase subunit beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM205426(US9243020, 27 | US9815861, Example 27)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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