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Report error Found 1325 Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid lipoxygenase ALOX15'
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM60832(US9181182, 23)
Affinity DataEC50:  1.24E+3nMT: 2°CAssay Description:Selected Compounds of the Examples were evaluated at Millipore Corporation, USA, using S1P1 receptor; [35S]-GTPgamaS binding assay. A [35S]-GTPgamaS ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM60833(US9181182, 33)
Affinity DataEC50: >2.40E+4nMT: 2°CAssay Description:Selected Compounds of the Examples were evaluated at Millipore Corporation, USA, using S1P1 receptor; [35S]-GTPgamaS binding assay. A [35S]-GTPgamaS ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM60834(US9181182, 30)
Affinity DataEC50: >5.54E+4nMT: 2°CAssay Description:Selected Compounds of the Examples were evaluated at Millipore Corporation, USA, using S1P1 receptor; [35S]-GTPgamaS binding assay. A [35S]-GTPgamaS ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM60835(US9181182, 63)
Affinity DataEC50: >4.00E+4nMT: 2°CAssay Description:Selected Compounds of the Examples were evaluated at Millipore Corporation, USA, using S1P1 receptor; [35S]-GTPgamaS binding assay. A [35S]-GTPgamaS ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50180653(CHEMBL3194617)
Affinity DataKd:  1.53E+4nMAssay Description:Binding affinity to wild-type His6-tagged human 15-LOX expressed in Escherichia coli Rosetta DE3 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50180654(CHEMBL3817975)
Affinity DataKd:  4.40E+3nMAssay Description:Binding affinity to wild-type His6-tagged human 15-LOX expressed in Escherichia coli Rosetta DE3 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50180652(CHEMBL3819527)
Affinity DataKd:  3.90E+3nMAssay Description:Binding affinity to wild-type His6-tagged human 15-LOX expressed in Escherichia coli Rosetta DE3 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572160(CHEMBL1452107)
Affinity DataEC50:  600nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(cid_3696046 | SMR000179722 | 1-phenyl-2-{[4-(trifl...)
Affinity DataEC50:  750nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238 | US20240317691, Compound 106)
Affinity DataEC50:  3.10E+4nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020 | US20240317691, Compound 107)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50109578(CHEMBL3604156)
Affinity DataIC50: 1nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347329(CHEMBL1796851)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347323(CHEMBL1796845)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347327(CHEMBL1796849)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50109729(CHEMBL3604185)
Affinity DataIC50: 2nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347324(CHEMBL1796846)
Affinity DataIC50: 2nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347327(CHEMBL1796849)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50516347(CHEMBL4531593)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of thymidylate synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347328(CHEMBL1796850)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22266({ethyl[(3R)-1-[1-(4-fluorophenyl)ethyl]pyrrolidin-...)
Affinity DataIC50: 3nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347325(CHEMBL1796847)
Affinity DataIC50: 3nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347329(CHEMBL1796851)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347322(CHEMBL1796844)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50109751(CHEMBL3604184)
Affinity DataIC50: 4nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347318(CHEMBL1796840)
Affinity DataIC50: 4nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347328(CHEMBL1796850)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347330(CHEMBL1795361)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347323(CHEMBL1796845)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347326(CHEMBL1796848)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22249(N-{2-[5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imi...)
Affinity DataIC50: 6nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22302(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50: 6nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347324(CHEMBL1796846)
Affinity DataIC50: 7nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347325(CHEMBL1796847)
Affinity DataIC50: 7nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347322(CHEMBL1796844)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22304(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Affinity DataIC50: 8nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347326(CHEMBL1796848)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50347319(CHEMBL1796841)
Affinity DataIC50: 9nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22265({ethyl[(3R)-1-(2-phenylpropan-2-yl)pyrrolidin-3-yl...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22303(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22305(N-[2-(2-{8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM22308(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50329324(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50329327(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50329325(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50329321(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50329328(4-(5-(naphthalen-2-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50329329(4-(5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-ylthio)but...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50329326(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Akaal Pharma

US Patent
LigandPNGBDBM50109578(CHEMBL3604156)
Affinity DataIC50: 10nMAssay Description:Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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