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Report error Found 28 Enz. Inhib. hit(s) with Target = 'Antithrombin-III'
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50421408(CHEMBL2303815)
Affinity DataKd:  1.90nMAssay Description:In vitro binding affinity against antithrombin III (AT III) was determined by fluorescence spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50421407(CHEMBL2303814)
Affinity DataKd:  2.80nMAssay Description:In vitro binding affinity against antithrombin III (AT III) was determined by fluorescence spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50369254(CHEMBL609990)
Affinity DataKd:  58nMAssay Description:Dissociation constant for Antithrombin-IIIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50369253(CHEMBL1909451)
Affinity DataKd:  7nMAssay Description:Dissociation constant for Antithrombin-IIIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50378854(IDRAPARINUX SODIUM)
Affinity DataKd:  1nMAssay Description:Binding affinity to antithrombin 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50037996(N-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-...)
Affinity DataIC50: 570nMAssay Description:Antithrombin III (ATIII)-mediated anti-Xa activity was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III/Prothrombin(Human)
University of Michigan

US Patent
LigandPNGBDBM264613(US9718760, C157)
Affinity DataIC50: 4.44E+4nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAntithrombin-III/Prothrombin(Human)
University of Michigan

US Patent
LigandPNGBDBM264597(US9718760, C152)
Affinity DataIC50: 8.70E+4nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAntithrombin-III/Coagulation factor X(Human)
Universidade Do Porto (Cequimed-Up)

Curated by ChEMBL
LigandPNGBDBM50393527(CHEMBL2158198)
Affinity DataIC50: 1.90E+5nMAssay Description:Inhibition of human factor 10a/antithrombin 3 assessed as CBS 31.39 substrate hydrolysis by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310299(N,N'-(ethane-1,2-diyl)bis(N-ethyl-3,4-dimethoxyben...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310309(N-(3,4-dihydroxyphenylsulfonyl)-N-hexyl-3,4-dihydr...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310311(N-cyclohexyl-N-(3,4-dihydroxyphenylsulfonyl)-3,4-d...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310310(N-benzyl-N-(3,4-dihydroxyphenylsulfonyl)-3,4-dihyd...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310306(N,N'-(ethane-1,2-diyl)bis(N-ethylbenzenesulfonamid...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310313(N,N'-(ethane-1,2-diyl)bis(N-ethyl-2,5-dihydroxyben...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310305(N,N'-(ethane-1,2-diyl)bis(N-ethyl-4-hydroxybenzene...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310312(N,N'-bis(3,4-dihydroxybenzenesulfonyl)piperazine |...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III/Prothrombin(Human)
University of Michigan

US Patent
LigandPNGBDBM264614(US9718760, C158)
Affinity DataIC50: 5.47E+5nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAntithrombin-III/Prothrombin(Human)
University of Michigan

US Patent
LigandPNGBDBM264598(US9718760, C155)
Affinity DataIC50: 2.33E+6nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAntithrombin-III/Prothrombin(Human)
University of Michigan

US Patent
LigandPNGBDBM264627(US9718760, C160)
Affinity DataIC50: 2.33E+6nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAntithrombin-III/Prothrombin(Human)
University of Michigan

US Patent
LigandPNGBDBM264648(US9718760, C161)
Affinity DataIC50: 1.67E+6nMT: 2°CAssay Description:PAI-1 inhibitor compounds were dissolved in DMSO to a final concentration of (10-50 mM), depending upon solubility. Compounds were then diluted in ph...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310301(N,N'-(ethane-1,2-diyl)bis(N-ethyl-3,4-dihydroxyben...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310300(N,N'-(ethane-1,2-diyl)bis(3,4-dihydroxybenzenesulf...)
Affinity DataIC50: 3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310308(N-(3,4-dihydroxyphenylsulfonyl)-3,4-dihydroxy-N-pr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310307(N,N'-(ethane-1,2-diyl)bis(N-ethyl-3,5-difluoro-4-h...)
Affinity DataIC50: 3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310304(N,N'-(ethane-1,2-diyl)bis(N-ethyl-3-hydroxybenzene...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310303(N,N'-(hexane-1,6-diyl)bis(3,4-dihydroxybenzenesulf...)
Affinity DataIC50: 3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAntithrombin-III(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50310302(N,N'-(butane-1,4-diyl)bis(3,4-dihydroxybenzenesulf...)
Affinity DataIC50: 3.00E+6nMAssay Description:Inhibition of antithrombin-3 assessed as residual alpha-thrombin activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed