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TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM50016706(CHEMBL63139 | Octahydro-indolizine-1,2,8-triol | S...)
Affinity DataIC50: 40nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84871(Swainsonine derivative, 6)
Affinity DataIC50: 44nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM688735(US20240190866, Compound ACK900)
Affinity DataIC50: 100nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM688738(US20240190866, Compound ACK903)
Affinity DataIC50: 190nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84870(Swainsonine derivative, 5)
Affinity DataIC50: 250nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84872(Swainsonine derivative, 7)
Affinity DataIC50: 250nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50367914(CHEMBL1794796)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50367915(CHEMBL1794797)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM688739(US20240190866, Compound ACK904)
Affinity DataIC50: 800nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM688736(US20240190866, Compound ACK901)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM688740(US20240190866, Compound ACK905)
Affinity DataIC50: 1.30E+3nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM688737(US20240190866, Compound ACK902)
Affinity DataIC50: 1.60E+3nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50016706(CHEMBL63139 | Octahydro-indolizine-1,2,8-triol | S...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50031484((2R,3R,4R)-1-Butyl-2-hydroxymethyl-pyrrolidine-3,4...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18353((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031482((2R,3R,4R,5R)-1-Butyl-2,5-bis-hydroxymethyl-pyrrol...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031483((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-1-methyl-pyrro...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50031480((2R,3R,4R)-2-Hydroxymethyl-1-methyl-pyrrolidine-3,...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031480((2R,3R,4R)-2-Hydroxymethyl-1-methyl-pyrrolidine-3,...)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84468(Mannostatin analogue, 4b | Meso-aminocyclopentitet...)
Affinity DataIC50: 1.00E+5nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50031484((2R,3R,4R)-1-Butyl-2-hydroxymethyl-pyrrolidine-3,4...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50403114(CHEMBL1337303)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50031483((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-1-methyl-pyrro...)
Affinity DataIC50: 1.90E+5nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50031481(2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypy...)
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM18353((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50031482((2R,3R,4R,5R)-1-Butyl-2,5-bis-hydroxymethyl-pyrrol...)
Affinity DataIC50: 8.50E+5nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50016704(Octahydro-indolizine-1,6,7,8-tetraol | CHEMBL46449...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50016708(CHEMBL303545 | 2-Hydroxymethyl-piperidine-3,4-diol)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84868(Swainsonine derivative, 3)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/mole IC50: 29nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84869(Swainsonine derivative, 4)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/mole IC50: 29nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84867(Swainsonine derivative, 2)
Affinity DataKi:  2.80nM ΔG°:  -48.8kJ/mole IC50: 30nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/mole IC50: 37nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM50078117(Mannostatin A, 1 | (1R,2R,3R,4S,5R)-4-Amino-5-meth...)
Affinity DataKi:  36nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM84465(Benzylation of mannostatin A, 1e)
Affinity DataKi:  50nM ΔG°:  -43.3kJ/molepH: 5.6 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM50088625(Mannostatin analogue, 5 | CHEMBL427643 | (1R,2R,3R...)
Affinity DataKi:  76nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM50078117(Mannostatin A, 1 | (1R,2R,3R,4S,5R)-4-Amino-5-meth...)
Affinity DataKi:  90nM ΔG°:  -41.8kJ/molepH: 5.6 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM84464(Benzylation of mannostatin A, 1d)
Affinity DataKi:  100nM ΔG°:  -41.6kJ/molepH: 5.6 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM84466(Benzylation of mannostatin A, 1f)
Affinity DataKi:  100nM ΔG°:  -41.6kJ/molepH: 5.6 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM84462(Benzylation of mannostatin A, 1b)
Affinity DataKi:  110nM ΔG°:  -41.3kJ/molepH: 5.6 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM84467(Benzylation of mannostatin A, 1g)
Affinity DataKi:  140nM ΔG°:  -40.7kJ/molepH: 5.6 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM84614(Mannostatin B, 2)
Affinity DataKi:  150nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2012
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Human)
Academia Sinica

US Patent
LigandPNGBDBM84474(Aminocyclopentitetrol, 2g)
Affinity DataKi:  160nM ΔG°:  -40.3kJ/molepH: 5.6 T: 2°CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2012
Entry Details Article
PubMed
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