Compile Data Set for Download or QSAR
Report error Found 191 Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member A1'
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 0.480nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621678(CHEMBL5397238)
Affinity DataIC50: 25nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
LigandPNGBDBM50009844(CHEMBL7480 | 2-fluorospiro[9H-fluorene-9,4'-(tetra...)
Affinity DataIC50: 27nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity was measured against renal inner medulla aldehyde reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 29nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621672(CHEMBL5431713)
Affinity DataIC50: 29nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621685(CHEMBL5396251)
Affinity DataIC50: 33nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
LigandPNGBDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 40nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621680(CHEMBL5400944)
Affinity DataIC50: 42nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 45nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldeh...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621678(CHEMBL5397238)
Affinity DataIC50: 48nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621670(CHEMBL5417323)
Affinity DataIC50: 51nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621687(CHEMBL5438141)
Affinity DataIC50: 53nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621676(CHEMBL5431549)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621676(CHEMBL5431549)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621674(CHEMBL5414200)
Affinity DataIC50: 59nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621677(CHEMBL5399554)
Affinity DataIC50: 63nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 65nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldeh...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621673(CHEMBL5418720)
Affinity DataIC50: 66nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621681(CHEMBL5400147)
Affinity DataIC50: 67nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621685(CHEMBL5396251)
Affinity DataIC50: 67nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621682(CHEMBL5414059)
Affinity DataIC50: 68nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621683(CHEMBL5400501)
Affinity DataIC50: 72nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621679(CHEMBL5421140)
Affinity DataIC50: 74nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621675(CHEMBL5413369)
Affinity DataIC50: 80nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621671(CHEMBL5397588)
Affinity DataIC50: 82nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621677(CHEMBL5399554)
Affinity DataIC50: 82nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621688(CHEMBL5483061)
Affinity DataIC50: 93nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621686(CHEMBL5423635)
Affinity DataIC50: 122nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50621684(CHEMBL5420064)
Affinity DataIC50: 127nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
LigandPNGBDBM50330615(4-Amino-N-(4-bromo-2-fluorobenzyl)-N-(3,5-difluoro...)
Affinity DataIC50: 323nMAssay Description:Inhibition of Fischer-344 rat kidney AK1A1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 325nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldeh...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member A1(Bovine)
Comsats Institute of Information Technology

LigandPNGBDBM193860((E)-3-(2-(2-((2-amino-4-chlorophenyl)(phenyl)methy...)
Affinity DataIC50: 459nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50126777(Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-2,3-dihy...)
Affinity DataIC50: 490nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 540nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50126780(Cyano-[5-fluoro-1-(4-methyl-benzyl)-2-oxo-2,3-dihy...)
Affinity DataIC50: 690nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 720nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member A1(Bovine)
Comsats Institute of Information Technology

LigandPNGBDBM193856((E)-3-(2-(2-(1-(3-fluoro-4-methoxyphenyl)ethyliden...)
Affinity DataIC50: 1.08E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...)
Affinity DataIC50: 1.20E+3nMAssay Description:Tested for in vitro inhibition activity against human aldehyde reductase (AHR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldeh...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 1.21E+3nMAssay Description:Evaluated for inhibition of Aldehyde reductase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member A1(Bovine)
Comsats Institute of Information Technology

LigandPNGBDBM193858((E)-3-(2-(2-(1-(4-hydroxy-3-methoxyphenyl)ethylide...)
Affinity DataIC50: 1.41E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibitory activity against rat kidney aldehyde reductase(ALR).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50241817(CHEMBL4081954)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human AKR1A1 using pyridine-3-aldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50241828(CHEMBL4089817)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human AKR1A1 using pyridine-3-aldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member A1(Bovine)
Comsats Institute of Information Technology

LigandPNGBDBM193852((E)-3-(2-(2-(1-(4-bromophenyl)ethylidene)hydraziny...)
Affinity DataIC50: 1.71E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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