Compile Data Set for Download or QSAR
Report error Found 767 Enz. Inhib. hit(s) with Target = 'ATP-binding cassette sub-family C member 2'
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50358848(CHEMBL1923433)
Affinity DataEC50:  1.45E+5nMAssay Description:Stimulation of ATPase activity of human MRP2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047316(CHEMBL3314525)
Affinity DataEC50:  7.10E+4nMAssay Description:Stimulation of ATPase activity of human MRP2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047200(CHEMBL3314564)
Affinity DataEC50: >2.00E+5nMAssay Description:Stimulation of ATPase activity of human MRP2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047213(CHEMBL3314565)
Affinity DataEC50: >2.00E+5nMAssay Description:Stimulation of ATPase activity of human MRP2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047215(CHEMBL3314567)
Affinity DataEC50: >2.00E+5nMAssay Description:Stimulation of ATPase activity of human MRP2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047309(CHEMBL3314576)
Affinity DataEC50:  1.40E+5nMAssay Description:Stimulation of ATPase activity of human MRP2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50358848(CHEMBL1923433)
Affinity DataEC50:  2.70E+4nMAssay Description:Stimulation of ATPase activity of rat Mrp2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047316(CHEMBL3314525)
Affinity DataEC50:  3.80E+4nMAssay Description:Stimulation of ATPase activity of rat Mrp2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047200(CHEMBL3314564)
Affinity DataEC50: >2.00E+5nMAssay Description:Stimulation of ATPase activity of rat Mrp2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047213(CHEMBL3314565)
Affinity DataEC50: >2.00E+5nMAssay Description:Stimulation of ATPase activity of rat Mrp2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047215(CHEMBL3314567)
Affinity DataEC50: >2.00E+5nMAssay Description:Stimulation of ATPase activity of rat Mrp2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50047309(CHEMBL3314576)
Affinity DataEC50:  1.10E+5nMAssay Description:Stimulation of ATPase activity of rat Mrp2 assessed as inorganic phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420230(CHEMBL2074750)
Affinity DataIC50: 100nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.05 uM) in bile canalicular membranes from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420229(CHEMBL2074720)
Affinity DataIC50: 120nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.05 uM) in bile canalicular membranes from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420221(CHEMBL325447)
Affinity DataIC50: 200nMAssay Description:TP_TRANSPORTER: inhibition of Naf-GlcA uptake (Naf-GlcA: 0.1 uM) in bile canalicular membrane vesicles of Wistar ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420229(CHEMBL2074720)
Affinity DataIC50: 280nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.05 uM) in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420230(CHEMBL2074750)
Affinity DataIC50: 400nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.05 uM) in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50485596(Leukotriene C4 | LEUKOTRIEN C4)
Affinity DataIC50: 650nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50013920(3-[(R)-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ABCC2 overexpressed in MDCK cells at 100 uM by flow cytometric-based chloromethylfluorescein-diacetate accumulation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataIC50: 2.41E+3nMAssay Description:Inhibition of human MRP2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 2.62E+3nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM172718(US9090657, Cyclosporine A, 1 | US11802108, Compoun...)
Affinity DataIC50: 3.10E+3nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50485596(Leukotriene C4 | LEUKOTRIEN C4)
Affinity DataIC50: 3.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake (PAH: 0.1uM) in membrane vesicles from MRP2-expressing HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50186231([2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]ace...)
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 4.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake (PAH: 0.1uM) in membrane vesicles from MRP2-expressing HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM172718(US9090657, Cyclosporine A, 1 | US11802108, Compoun...)
Affinity DataIC50: 4.10E+3nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202456(CHEMBL3974624)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202441(CHEMBL3263914)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202445(CHEMBL3921707)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202442(CHEMBL3263916)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563665(CHEMBL4785754)
Affinity DataIC50: 5.00E+3nMAssay Description:Reversal of MRP2-mediated multidrug resistance in human KBV cells assessed as cisplatin IC50 at 5 uM after 72 hrs in presence of cisplatin by MTT ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563666(CHEMBL4760910)
Affinity DataIC50: 5.00E+3nMAssay Description:Reversal of MRP2-mediated multidrug resistance in human KBV cells assessed as cisplatin IC50 at 5 uM after 72 hrs in presence of cisplatin by MTT ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563665(CHEMBL4785754)
Affinity DataIC50: 5.00E+3nMAssay Description:Reversal of MRP2-mediated multidrug resistance in human KBV cells assessed as cisplatin IC50 at 10 uM after 72 hrs in presence of cisplatin by MTT as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563666(CHEMBL4760910)
Affinity DataIC50: 5.00E+3nMAssay Description:Reversal of MRP2-mediated multidrug resistance in human KBV cells assessed as cisplatin IC50 at 10 uM after 72 hrs in presence of cisplatin by MTT as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 5.00E+3nMAssay Description:Reversal of MRP2-mediated multidrug resistance in human KBV cells assessed as cisplatin IC50 at 10 uM after 72 hrs in presence of cisplatin by MTT as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50292408(5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-...)
Affinity DataIC50: 5.48E+3nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202454(CHEMBL3263915)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202446(CHEMBL3964042)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103642(CHEMBL308954 | TMC-125 | TMC 125 | 4-(6-amino-5-br...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of MRP2 expressed in MDCK2 cells assessed as cell growth inhibition by calcein and pheophorbide A efflux assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202451(CHEMBL3945493)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202452(CHEMBL3263569)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50297387((5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-car...)
Affinity DataIC50: 9.83E+3nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MRP2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50013920(3-[(R)-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50485605(Leukotriene F4 | LEUKOTRIEN F4)
Affinity DataIC50: 1.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378783(CLOFAZIMINE)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202453(CHEMBL3263906)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202459(CHEMBL3263904)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50202458(CHEMBL3263570)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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