Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with Target = 'A disintegrin and metalloproteinase with thrombospondin motifs 1'
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50: 79nMAssay Description:Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrsMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379555(US9926281, Compound 34)
Affinity DataIC50: 328nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379599(US9926281, Compound 96)
Affinity DataIC50: 631nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379979(US9926281, Compound 438)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379697(US9926281, Compound 255)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379975(US9926281, Compound 436)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379760(US9926281, Compound 220 | US9926281, Compound 425)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379924(US9926281, Compound 410)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM379958(US9926281, Compound 457)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379634(US9926281, Compound 152)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM379962(US9926281, Compound 459)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM379751(US9926281, Compound 407)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50122449(CHEMBL3622483)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS13 using FRETSVWF73 as substrate by fluorescence assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50431942(CHEMBL2347847)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ADAMTS-13 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM379558(US9926281, Compound 40)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM379557(US9926281, Compound 36)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50431947(CHEMBL2348091)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of ADAMTS-13 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50575689(CHEMBL4850670)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575718(CHEMBL4873384)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50395680(CHEMBL2164120)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50395679(CHEMBL2164121)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50395678(CHEMBL2164122)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50395677(CHEMBL2164111)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50395676(CHEMBL2164113)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50395675(CHEMBL2164094)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM379697(US9926281, Compound 255)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ADAMTS13 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50183711(N-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-4-yl)-...)
Affinity DataKi:  776nMAssay Description:Binding affinity to ADAMTS1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of ADAMTS1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50183715(N-(4-(2-(hydroxyamino)-2-oxoethyl)tetrahydro-2H-py...)
Affinity DataKi:  7.80E+3nMAssay Description:Inhibition of ADAMTS1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50265114(N-((2R,6S)-4-(2-(hydroxyamino)-2-oxoethyl)-2,6-dim...)
Affinity DataKi:  7.80E+3nMAssay Description:Inhibition of ADAMTS1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50183715(N-(4-(2-(hydroxyamino)-2-oxoethyl)tetrahydro-2H-py...)
Affinity DataKi:  7.80E+3nMAssay Description:Binding affinity to ADAMTS1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed