Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with Target = '4-hydroxy-3-methylbut-2-enyl diphosphate reductase'
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487150(BUT-3-YNYL DIPHOSPHATE)
Affinity DataIC50: 450nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487160(PENT-4-YNYL DIPHOSPHATE)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487156(PROP-2-YNYL DIPHOSPHATE)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487149(PYRIDIN-3-YL-ETHYL-DIPHOSPHATE)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487155(4-HYDROXYBUT-2-YNYL DIPHOSPHATE)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487157(CHEMBL2251817)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487159(2-CYANOETHYL DIPHOSPHATE)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50113291([(4-Methyl-pyridin-2-ylamino)-phosphono-methyl]-ph...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487161((PYRIDIN-4-YL)-METHYL-DIPHOSPHATE)
Affinity DataIC50: 1.49E+5nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487148(CYANOMETHYL DIPHOSPHATE)
Affinity DataIC50: 2.45E+5nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487151(PYRIDIN-3-YL-PROPYL-DIPHOSPHATE)
Affinity DataIC50: 4.63E+5nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098378(2-(2-Hydroxy-2,2-bis-phosphono-ethyl)-pyridinium |...)
Affinity DataIC50: 4.85E+5nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50165342(hydrogen 1-hydroxy-2-(3-methylpyridinium-1-yl)-1-p...)
Affinity DataIC50: 5.40E+5nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487153(CHEMBL2251816)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115106([2-(2-pyridinylamino)ethylidene]-1,1-bisphosphonat...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487152(CHEMBL2251820)
Affinity DataIC50: 3.70E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50373099(NE-10575 | CHEMBL99553)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487154(CHEMBL2251815)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12576(JMC515594 Compound 64 | Risdronate | CHEMBL923 | R...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138725((1-phosphono-2-pyridin-3-yl-ethyl)-phosphonic acid...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487158((PYRIDIN-2-YL)-METHYL-DIPHOSPHATE)
Affinity DataIC50: 1.20E+6nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487150(BUT-3-YNYL DIPHOSPHATE)
Affinity DataKi:  60nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Illinois

LigandPNGBDBM228817(IspH inhibitor, 8)
Affinity DataKi:  500nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM228818(8-Amino-3-benzyl-2,3,4,4 a-tetrahydro-1,2'H,6H...)
Affinity DataKi:  700nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus (strain VF5))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50487149(PYRIDIN-3-YL-ETHYL-DIPHOSPHATE)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Escherichia coli (strain K12))
University of Illinois

LigandPNGBDBM228818(8-Amino-3-benzyl-2,3,4,4 a-tetrahydro-1,2'H,6H...)
Affinity DataKi:  3.00E+3nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed