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Report error Found 589 Enz. Inhib. hit(s) with Target = '2-Hydroxyacid oxidase 1'
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463040(CHEMBL4247590)
Affinity DataEC50:  8.36E+3nMAssay Description:Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463042(CHEMBL4237565)
Affinity DataEC50:  7.88E+3nMAssay Description:Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463040(CHEMBL4247590)
Affinity DataEC50:  3.45E+3nMAssay Description:Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  2.53E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 24 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  3.40E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 72 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  3.30E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 48 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463042(CHEMBL4237565)
Affinity DataEC50:  3.59E+3nMAssay Description:Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463040(CHEMBL4247590)
Affinity DataEC50:  1.12E+4nMAssay Description:Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Universidad De Granada

Curated by ChEMBL
LigandPNGBDBM50463042(CHEMBL4237565)
Affinity DataEC50:  9.20E+3nMAssay Description:Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as reduction in oxalate production after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50581734(CHEMBL5081182)
Affinity DataEC50:  1.70E+4nMAssay Description:Inhibition of human recombinant HAO1 expressed in CHO cells co-transformed with a vector expressing glycolate oxidase assessed as cell rescue from CH...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581194(US11504367, Example 291 | 5-(4-(2-(3-chlorophenyl)...)
Affinity DataIC50: 0.300nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581193(US11504367, Example 290 | 5-(4-(2-(4-chlorophenyl)...)
Affinity DataIC50: 0.400nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50572931(CHEMBL4855986)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581140(US11504367, Example 108 | 5-(4-(()ethynyl)phenoxy)...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581143(US11504367, Example 146 | 5-(3-fluoro-4- (phenyle...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581148(US11504367, Example 187 | 5-(3-((3- chlorophenyl)...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581155(US11504367, Example 221 | 5-(3-(2-(1-methyl-1H-pyr...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581159(US11504367, Example 257 | 5-(3-((1-methyl-2-oxo-1,...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581161(US11504367, Example 259 | 5-(4-fluoro-3-(2- pheny...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581164(US11504367, Example 262 | 5-(4-methyl-3-(2- pheny...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581170(US11504367, Example 268 | 5-(3-((4- cyanophenyl)e...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581171(US11504367, Example 269 | 5-(4-((4- cyanophenyl)e...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581172(US11504367, Example 270 | 5-(4-((3- cyanophenyl)e...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581180(US11504367, Example 278 | 5-(4-(2-(3-fluorophenyl)...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581191(US11504367, Example 288 | 5-(4-(2-(4-fluorophenyl)...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581192(US11504367, Example 289 | 5-(3-(2-(4-fluorophenyl)...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581198(US11504367, Example 295 | 5-(3-(2-(6-methylpyridin...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581199(US11504367, Example 296 | 5-(3-(2-(2-methylpyridin...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581211(US11504367, Example 307 | 5-(3-(2-(1H-indazol-5- ...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581232(US11504367, Example 328 | 5-(3-(2-(1H-indazol-4- ...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581234(US11504367, Example 330 | 5-(3-(2-(1H-indazol-6- ...)
Affinity DataIC50: 1nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50572932(CHEMBL4850573)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581151(US11504367, Example 208 | 5-(4-((1-methyl-6-oxo-1,...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581158(US11504367, Example 256 | 5-(4-((1-methyl-2-oxo-1,...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581160(US11504367, Example 258 | 5-(3-fluoro-5-(2- pheny...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581165(US11504367, Example 263 | 5-(4-(trifluoromethyl)-3...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581168(US11504367, Example 266 | 5-(4-fluoro-3-(2-(4- (m...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581169(US11504367, Example 267 | 5-(4-fluoro-3-(2-(3- (m...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581173(US11504367, Example 271 | 5-(4-((3- cyanophenyl)e...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581174(US11504367, Example 272 | 5-(3-fluoro-4-(2-(4- (m...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581175(US11504367, Example 273 | 5-(3-fluoro-4-(2-(3- (m...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581179(US11504367, Example 277 | 4-(3-((3-cyanophenyl) e...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581181(US11504367, Example 279 | 5-(3-(2-(3-fluorophenyl)...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581183(US11504367, Example 281 | 5-(4-(2-(3- methoxyphen...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581195(US11504367, Example 292 | 5-(3-(2-(4-chlorophenyl)...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581219(US11504367, Example 315 | 5-(3-(2-(1-methyl-1H-ind...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581220(US11504367, Example 316 | 5-(4-(2-(1-methyl-1H-ind...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581221(US11504367, Example 317 | 5-(3-(2-(1-methyl-1H-ind...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target2-Hydroxyacid oxidase 1(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM581222(US11504367, Example 318 | 5-(4-(2-(1-methyl-1H-ind...)
Affinity DataIC50: 2nMAssay Description:The in-vitro glycolate oxidase assay was performed using recombinant full-length human hydroxyacid oxidase 1 (HAO1), the equivalents of hGOX. The enz...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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