BDBM8611 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonitrile::CHEMBL468419::CHEMBL9298::Fadrozole::US9271963, Fadrozole
SMILES N#Cc1ccc(cc1)C1CCCc2cncn12
InChI Key InChIKey=CLPFFLWZZBQMAO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 90 hits for monomerid = 8611
Affinity DataIC50: 30nMAssay Description:Inhibition of human placental CYP19More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B1 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human placental CYP19 using [1beta-3H]androstenedione substrateMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human placental CYP19 using androstenedione as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of aromatase (unknown origin) transfected in human MCF7 cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human placental CYP19More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of human aromataseMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Mouse)
Roche Pharma Research and Early Development (Pred)
Curated by ChEMBL
Roche Pharma Research and Early Development (Pred)
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of mouse CYP11B2 expressed in renal leiomyoblastoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human CYP11B2 expressed in renal leiomyoblastoma cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human adrenal corticoid CYP11B1 expressed in chinese hamster V79 MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human adrenal corticoid CYP11B2 expressed in chinese hamster V79 MZh cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of aromatase in human placental microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of CYP19 in human placental microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ACTH-stimulated aldosterone production in rat adrenal tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:In vitro inhibition of estrogen production in hamster ovarian tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human aromatase cytochrome P450 19A1 activityMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 8.00E+4nMAssay Description:In vitro inhibition of ACTH-stimulated corticosterone biosynthesis in rat adrenal slicesMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slicesMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli co-expressing rat NADPH-P450-reductase using progesterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human placental CYP19 using [1beta-3H]androstenedione as substrate by 3H2O-methodMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human CYP19 using [1beta-3H]androstenedione as substrate by 3H2O methodMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of CYP19 in human placental microsomes using [1beta-3H]-androstendione as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging methodMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging methodMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human placental CYP19 using androstenedione substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human aromatase using dibenzylfluorescein substrate preincubated for 30 mins measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Universita` Degli Studi Di Bari Aldo Moro
Curated by ChEMBL
Affinity DataIC50: 9.70nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair