BDBM79021 (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride::MLS001401398::NCGC00092386::SMR000466298::Sertraline::[(1S,4S)-4-(3,4-dichlorophenyl)tetralin-1-yl]-methyl-amine;hydrochloride::cid_63009

SMILES CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12

InChI Key InChIKey=VGKDLMBJGBXTGI-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 79021   

TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetArachidonate 15-lipoxygenase(Pseudomonas aeruginosa)
University of California Santa Cruz

LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 1.31E+4nMT: 2°CAssay Description:Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rat)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 2.97E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 720nMAssay Description:Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 520nMAssay Description:Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM79021(Sertraline | SMR000466298 | cid_63009 | (1S,4S)-4-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed