BDBM7646 CHEMBL102926::Imidazo[1,2-a]pyridine deriv. 6::N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}-4-{2-methylimidazo[1,2-a]pyridin-3-yl}pyrimidin-2-amine

SMILES CN(C)CC(O)COc1ccc(Nc2nccc(n2)-c2c(C)nc3ccccn23)cc1

InChI Key InChIKey=VCPXSBULBDYRLT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7646   

LigandPNGBDBM7646(N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}-4...)
Affinity DataIC50: 32nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM7646(N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}-4...)
Affinity DataIC50: 150nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM7646(N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}-4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM7646(N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}-4...)
Affinity DataIC50: 32nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Rational Discovery

Curated by ChEMBL
LigandPNGBDBM7646(N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Cyclin-dependent kinase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Rational Discovery

Curated by ChEMBL
LigandPNGBDBM7646(N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}-4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed